open access

Vol 2, No 3 (2017)
Review article
Published online: 2018-01-31
Get Citation

Angiogenesis in Hodgkin’s lymphoma

Jan Filipiak12, Joanna Boińska1, Danuta Rość1
·
Medical Research Journal 2017;2(3):83-88.
Affiliations
  1. Department of Pathophysiology, Faculty of Pharmacy, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, Curie Skłodowskiej 9, 85-094 Bydgoszcz, Poland
  2. Department of Chemotherapy, Oncology Centre-Prof. Franciszek Łukaszczyk Memorial Hospital, Romanowskiej 2, 85-796 Bydgoszcz, Poland

open access

Vol 2, No 3 (2017)
REVIEW ARTICLES
Published online: 2018-01-31

Abstract

Angiogenesis is a multistep process controlled by a number of stimulating and inhibiting factors. Aberrant angiogenesis is involved in cancer progression. The best-known elements responsible for regulation of angiogenesis are vascular endothelial growth factor, their membrane-bound receptors, and circulating, soluble receptors. The major objective of the present review is twofold: firstly, it seeks to explore knowledge about angiogenesis in Hodgkin’s lymphoma, and secondly it indicates the necessity and relevance of carrying out further research dedicated to this process. Hodgkin’s lymphoma is a proliferative disease of the lymphatic system. The process of angiogenesis in Hodgkin’s lymphoma has not been studied thoroughly. There is a significant role of paracrine interactions of Hodgkin and Reed-Sternberg cells with reactive cells of the immune system, which makes studying the mechanisms of development of Hodgkin’s lymphoma more difficult. It has been proven that several angiogenesis-stimulating proteins are expressed in Hodgkin and Reed-Sternberg cells both in vitro and in tumour tissue. Moreover, some of these proteins are produced by the reactive cells. Vascular endothelial growth factor, basic fibroblast growth factor, and hepatic growth factor serum concentrations are elevated in patients with Hodgkin’s lymphoma. The role of circulating endothelial progenitor cells in the pathogenesis of Hodgkin’s lymphoma has not been thoroughly explained. Similarly, there are no satisfying data on the modulation of the angiogenic potential of the blood caused by vascular endothelial growth factor soluble receptors in patients with Hodgkin’s lymphoma. Processes controlling angiogenesis in Hodgkin’s lymphoma merit more comprehensive investigation.

Abstract

Angiogenesis is a multistep process controlled by a number of stimulating and inhibiting factors. Aberrant angiogenesis is involved in cancer progression. The best-known elements responsible for regulation of angiogenesis are vascular endothelial growth factor, their membrane-bound receptors, and circulating, soluble receptors. The major objective of the present review is twofold: firstly, it seeks to explore knowledge about angiogenesis in Hodgkin’s lymphoma, and secondly it indicates the necessity and relevance of carrying out further research dedicated to this process. Hodgkin’s lymphoma is a proliferative disease of the lymphatic system. The process of angiogenesis in Hodgkin’s lymphoma has not been studied thoroughly. There is a significant role of paracrine interactions of Hodgkin and Reed-Sternberg cells with reactive cells of the immune system, which makes studying the mechanisms of development of Hodgkin’s lymphoma more difficult. It has been proven that several angiogenesis-stimulating proteins are expressed in Hodgkin and Reed-Sternberg cells both in vitro and in tumour tissue. Moreover, some of these proteins are produced by the reactive cells. Vascular endothelial growth factor, basic fibroblast growth factor, and hepatic growth factor serum concentrations are elevated in patients with Hodgkin’s lymphoma. The role of circulating endothelial progenitor cells in the pathogenesis of Hodgkin’s lymphoma has not been thoroughly explained. Similarly, there are no satisfying data on the modulation of the angiogenic potential of the blood caused by vascular endothelial growth factor soluble receptors in patients with Hodgkin’s lymphoma. Processes controlling angiogenesis in Hodgkin’s lymphoma merit more comprehensive investigation.

Get Citation

Keywords

angiogenesis, Hodgkin’s lymphoma, vascular endothelial growth factor

About this article
Title

Angiogenesis in Hodgkin’s lymphoma

Journal

Medical Research Journal

Issue

Vol 2, No 3 (2017)

Article type

Review article

Pages

83-88

Published online

2018-01-31

Page views

974

Article views/downloads

1003

DOI

10.5603/MRJ.2017.0010

Bibliographic record

Medical Research Journal 2017;2(3):83-88.

Keywords

angiogenesis
Hodgkin’s lymphoma
vascular endothelial growth factor

Authors

Jan Filipiak
Joanna Boińska
Danuta Rość

References (33)
  1. Banyś A. Angiogeneza w chorobie nowotworowej. Farm Pol. 2009; 65(4): 247–250.
  2. Granger D, Senchenkova E. Inflammation and the Microcirculation. Colloquium Series on Integrated Systems Physiology: From Molecule to Function. 2010; 2(1): 1–87.
  3. Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971; 285(21): 1182–1186.
  4. Langer R, Folkman J. Polymers for the sustained release of proteins and other macromolecules. Nature. 1976; 263(5580): 797–800.
  5. Kaelin WG. The von Hippel-Lindau Tumor Suppressor Protein and Clear Cell Renal Carcinoma. Clinical Cancer Research. 2007; 13(2).
  6. Rafii S, Lyden D, Benezra R, et al. Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? Nat Rev Cancer. 2002; 2(11): 826–835.
  7. Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003; 9(6): 669–676.
  8. Wojciechowska U, Didkowska J. Cancer in Poland in 2014. Polish National Cancer Registry. . Department of Epidemiology and Cancer Prevention. Maria Skłodowska-Curie Institute of Oncology, Warszawa 2016.
  9. Ansell SM. Hodgkin lymphoma: 2016 update on diagnosis, risk-stratification, and management. Am J Hematol. 2016; 91(4): 434–442.
  10. Cheson BD, Fisher RI, Barrington SF, et al. Alliance, Australasian Leukaemia and Lymphoma Group, Eastern Cooperative Oncology Group, European Mantle Cell Lymphoma Consortium, Italian Lymphoma Foundation, European Organisation for Research, Treatment of Cancer/Dutch Hemato-Oncology Group, Grupo Español de Médula Ósea, German High-Grade Lymphoma Study Group, German Hodgkin's Study Group, Japanese Lymphorra Study Group, Lymphoma Study Association, NCIC Clinical Trials Group, Nordic Lymphoma Study Group, Southwest Oncology Group, United Kingdom National Cancer Research Institute. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 2014; 32(27): 3059–3068.
  11. Cuccaro A, Bartolomei F, Cupelli E, et al. Prognostic factors in hodgkin lymphoma. Mediterr J Hematol Infect Dis. 2014; 6(1): e2014053.
  12. Locatelli SL, Careddu G, Chierchia A, et al. Synergistic induction of cell death in Hodgkin Lymphoma cells by the novel PI3K inhibitor RP6530 combined with brentuximab vendotin (SGN-35) through inhibition of tumor angiogenesis. Blood. 2016; 126(23): 1561.
  13. Kowalska M, Tajer J, Chechlinska M, et al. Discriminant analysis involving serum cytokine levels and prediction of the response to therapy of patients with Hodgkin lymphoma. Tumour Biol. 2012; 33(5): 1733–1738.
  14. Ben Arush MW, Ben Barak A, Maurice S, et al. Serum VEGF as a significant marker of treatment response in hodgkin lymphoma. Pediatr Hematol Oncol. 2007; 24(2): 111–115.
  15. Khnykin D, Troen G, Berner JM, et al. The expression of fibroblast growth factors and their receptors in Hodgkin's lymphoma. J Pathol. 2006; 208(3): 431–438.
  16. Korkolopoulou P, Thymara I, Kavantzas N, et al. Angiogenesis in Hodgkin's lymphoma: a morphometric approach in 286 patients with prognostic implications. Leukemia. 2005; 19(6): 894–900.
  17. Doussis-Anagnostopoulou IA, Talks KL, Turley H, et al. Vascular endothelial growth factor (VEGF) is expressed by neoplastic Hodgkin-Reed-Sternberg cells in Hodgkin's disease. J Pathol. 2002; 197(5): 677–683.
  18. Citak EC, Oguz A, Karadeniz C, et al. Immunohistochemical expression of angiogenic cytokines in childhood Hodgkin lymphoma. Pathol Res Pract. 2008; 204(2): 89–96.
  19. Passam FH, Alexandrakis MG, Kafousi M, et al. Histological expression of angiogenic factors: VEGF, PDGFRalpha, and HIF-1alpha in Hodgkin lymphoma. Pathol Res Pract. 2009; 205(1): 11–20.
  20. Mainou-Fowler T, Angus B, Miller S, et al. Micro-vessel density and the expression of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PdEGF) in classical Hodgkin lymphoma (HL). Leuk Lymphoma. 2006; 47(2): 223–230.
  21. Mizuno H, Nakayama T, Miyata Y, et al. Mast cells promote the growth of Hodgkin's lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib. Leukemia. 2012; 26(10): 2269–2276.
  22. Dimtsas GS, Georgiadi EC, Karakitsos P, et al. Prognostic significance of immunohistochemical expression of the angiogenic molecules vascular endothelial growth factor-A, vascular endothelial growth factor receptor-1 and vascular endothelial growth factor receptor-2 in patients with classical Hodgkin lymphoma. Leuk Lymphoma. 2014; 55(3): 558–564.
  23. Gharbaran R, Goy A, Tanaka T, et al. Fibroblast growth factor-2 (FGF2) and syndecan-1 (SDC1) are potential biomarkers for putative circulating CD15+/CD30+ cells in poor outcome Hodgkin lymphoma patients. J Hematol Oncol. 2013; 6: 62.
  24. Koh YW, Park CS, Yoon DH, et al. CD163 expression was associated with angiogenesis and shortened survival in patients with uniformly treated classical Hodgkin lymphoma. PLoS One. 2014; 9(1): e87066.
  25. Glimelius I, Edström A, Fischer M, et al. Angiogenesis and mast cells in Hodgkin lymphoma. Leukemia. 2005; 19(12): 2360–2362.
  26. Steidl C, Connors JM, Gascoyne RD. Molecular pathogenesis of Hodgkin's lymphoma: increasing evidence of the importance of the microenvironment. J Clin Oncol. 2011; 29(14): 1812–1826.
  27. Giles F, Vose J, Do KA, et al. Clinical relevance of circulating angiogenic factors in patients with non-Hodgkin’s lymphoma or Hodgkin’s lymphoma. Leukemia Research. 2004; 28(6): 595–604.
  28. Rueda A, Olmos D, Villareal V, et al. Elevated vascular endothelial growth factor pretreatment levels are correlated with the tumor burden in Hodgkin lymphoma and continue to be elevated in prolonged complete remission. Clin Lymphoma Myeloma. 2007; 7(6): 400–405.
  29. Okur FV, Karadeniz C, Buyukpamukcu M, et al. Clinical significance of serum vascular endothelial growth factor, endostatin, and leptin levels in children with lymphoma. Pediatr Blood Cancer. 2010; 55(7): 1272–1277.
  30. Sobol G, Mizia-Malarz A, Woś H. Serum concentrations of proangiogenic cytokines (VEGF, bFGF) depending on the histopathological types of Hodgkin lymphoma in children – preliminary report. Acta Haematologica Polonica. 2012; 43(4): 355–360.
  31. Rueda A, Olmos D, Vicioso L, et al. Role of vascular endothelial growth factor C in classical Hodgkin lymphoma. Leuk Lymphoma. 2015; 56(5): 1286–1294.
  32. Marinaccio C, Nico B, Maiorano E, et al. Insights in Hodgkin Lymphoma angiogenesis. Leuk Res. 2014; 38(8): 857–861.
  33. Jarosz P, Wożniak B. Angiogenesis in cancer diseases. Przegląd Medyczny Uniwersytetu Rzeszowskiego i Narodowego Instytutu Leków w Warszawie. 2012; 4: 498–507.

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By VM Media Group sp. z o.o., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: viamedica@viamedica.pl