Vol 9, No 1 (2024)
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Published online: 2024-02-15

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Impact of early levosimendan administration in patients with decompensated chronic heart failure on oxidative stress parameters — the rationale and study design

Ewa Laskowska1, Anna Stefańska2, Magdalena Krintus2, Jacek Kubica1
Medical Research Journal 2024;9(1):48-52.

Abstract

Oxidative stress plays a key role in the development of heart failure. The study is a phase III, single-centre,
randomized, double-blind, clinical trial that assesses the influence of early intravenous levosimendan
administration in patients with decompensated CHF on oxidative stress parameters and the function of
enzymatic antioxidative mechanisms. A total of 50 patients with diagnosed CHF with reduced ejection
fraction, LVEF ≤ 35% are randomized in a 1:1 ratio to receive either levosimendan or dobutamine. The
hypothesis is that levosimendan in patients with decompensated heart failure may reduce ROS production
and/or enhance antioxidant protection. MDA and LPO concentrations and the activity of antioxidant
enzymes SOD, GPX, GR, and CAT will be measured in plasma samples.

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