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Vol 9, No 1 (2024)
Original article
Published online: 2023-12-22
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The impact of complete blood count-derived indices (RDW, PDW and NLR) on 4 years outcomes in patients after PCI with sirolimus-eluting stent, including complex high-risk index procedure (CHIP) patients

Maciej Tyczyński1, Adam Kern2, Patryk Buller3, Robert J. Gil4, Jacek Bil1
DOI: 10.5603/mrj.98541
·
Medical Research Journal 2024;9(1):11-22.
Affiliations
  1. Department of Invasive Cardiology, Centre of Postgraduate Medical Education, Warsaw, Poland
  2. Department of Cardiology and Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland
  3. Department of Cardiology, Provincial Integrated Hospital, Plock, Poland
  4. Department of Cardiology, State Medical Institute of the Ministry of Interior and Administration, Warsaw, Poland

open access

Vol 9, No 1 (2024)
ORIGINAL ARTICLES
Published online: 2023-12-22

Abstract

Introduction: The authors analysed red cell distribution width (RDW), platelet distribution width (PDW), and
the neutrophil-to-lymphocyte ratio (NLR) as potential predicting factors of adverse outcomes in patients
after percutaneous coronary intervention (PCI) at 48 months follow-up.

Material and methods: The authors gathered data on subjects who underwent PCI with a sirolimus-eluting
Alex Plus stent (Balton, Poland). They characterized the rate of major adverse cardiovascular events
(MACE) over a 4-year period, which encompassed cardiac death, myocardial infarction (MI), and target
lesion revascularization (TLR) depending on the RDW, PDW, and NLR values.

Results: Included were 218 patients (256 stents), among which were also identified 77 complex, high-risk
index procedure (CHIP) patients and 73 high bleeding risk (HBR) patients. The authors identified only RDW
as having a significant impact on long-term outcomes and only in the total population and CHIP patients.
The total population with RDW > 14.5% was characterized by higher age (67 ± 11 vs. 73 ± 10 years,
p < 0.01) and higher incidence of chronic kidney disease (14% vs. 39%, p < 0.01) as well as chronic
obstructive pulmonary disease (4% vs. 15%, p = 0.024). Interestingly, this group had a lower rate of ACS
(42% vs. 34%, p = 0.049). At 48 months in the total population with RDW > 14.5% of patients, the rates
of MACE, cardiac death, MI, and TLR were 26.8%, 19.5%, 9.8%, and 12.2%, respectively.

Conclusions: RDW > 14.5% correlated with a higher risk of cardiac death in the total population and
CHIP patients.

Abstract

Introduction: The authors analysed red cell distribution width (RDW), platelet distribution width (PDW), and
the neutrophil-to-lymphocyte ratio (NLR) as potential predicting factors of adverse outcomes in patients
after percutaneous coronary intervention (PCI) at 48 months follow-up.

Material and methods: The authors gathered data on subjects who underwent PCI with a sirolimus-eluting
Alex Plus stent (Balton, Poland). They characterized the rate of major adverse cardiovascular events
(MACE) over a 4-year period, which encompassed cardiac death, myocardial infarction (MI), and target
lesion revascularization (TLR) depending on the RDW, PDW, and NLR values.

Results: Included were 218 patients (256 stents), among which were also identified 77 complex, high-risk
index procedure (CHIP) patients and 73 high bleeding risk (HBR) patients. The authors identified only RDW
as having a significant impact on long-term outcomes and only in the total population and CHIP patients.
The total population with RDW > 14.5% was characterized by higher age (67 ± 11 vs. 73 ± 10 years,
p < 0.01) and higher incidence of chronic kidney disease (14% vs. 39%, p < 0.01) as well as chronic
obstructive pulmonary disease (4% vs. 15%, p = 0.024). Interestingly, this group had a lower rate of ACS
(42% vs. 34%, p = 0.049). At 48 months in the total population with RDW > 14.5% of patients, the rates
of MACE, cardiac death, MI, and TLR were 26.8%, 19.5%, 9.8%, and 12.2%, respectively.

Conclusions: RDW > 14.5% correlated with a higher risk of cardiac death in the total population and
CHIP patients.

Full Text:

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Keywords

SES; PCI; Alex Plus; target lesion revascularization; thin-strut stent

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Title

The impact of complete blood count-derived indices (RDW, PDW and NLR) on 4 years outcomes in patients after PCI with sirolimus-eluting stent, including complex high-risk index procedure (CHIP) patients

Journal

Medical Research Journal

Issue

Vol 9, No 1 (2024)

Article type

Original article

Pages

11-22

Published online

2023-12-22

Page views

168

Article views/downloads

60

DOI

10.5603/mrj.98541

Bibliographic record

Medical Research Journal 2024;9(1):11-22.

Keywords

SES
PCI
Alex Plus
target lesion revascularization
thin-strut stent

Authors

Maciej Tyczyński
Adam Kern
Patryk Buller
Robert J. Gil
Jacek Bil

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