Vol 9, No 1 (2024)
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Published online: 2024-02-02

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Influence on polymorphism of visfatin (rs 4730153) and nesfatin (rs 1330) genes on the development of the metabolic syndrome

Małgorzata Poręba1, Agata Macionga1, Anna Gogola1, Nikola Szweda-Gandor1, Władysław Grzeszczak (†)1
Medical Research Journal 2024;9(1):42-47.


Introduction: Visfatin and nesfatin are active proteins that are involved in the regulation of physiological
functions such as glucose metabolism and inflammatory response. This study aimed to assess the influence
of visfatins and nystatins gene variants on the occurrence of the full metabolic syndrome or its components.

Material and methods: The research cohort comprised 285 diabetic patients, 132 men and 153 women.
Specific DNA segments were amplified and labelled, and the rs 4730153 gene of visfatin and the rs 1330
gene of nesfatin were analysed. Real-Time PCR was conducted using fluorescence-labelled probes.

Results: The AA genotype of visfatin (rs 4730153) shows a positive association with glucose concentration
or pharmacological treatment in patients with type 2 diabetes, compared to AG and GG genotypes. The
GG genotype of nesfatin (rs 1330) shows a positive association with incidents of metabolic syndrome,
compared to the AA genotype.

Conclusions: Visfatin polymorphism in rs 4730153 may be associated with inappropriate glucose concentration.
Nesfatin polymorphism in rs 1330 may be associated with metabolic syndrome. Further studies in
a larger group of patients are necessary to completely assess this association.

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