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Graft loss from a living donor due to flash recurrence of focal segmental glomerular sclerosis — case report
Affiliations- Hospital of the MSWiA in Kielce named after St. John Paul II, Kielce, Poland
- Collegium Medicum UJK, Kielce, Poland
- Provincial Specialist Hospital of St. Raphael in Czerwona Gora
- Collegium Medicum UJK, Kielce, Poland
- Clinical Department of Nephrology with Dialysis Station, Provincial Hospital Complex in Kielce
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Abstract
Focal segmental glomerular sclerosis is a pattern of histological damage of the kidney. The most common clinical manifestation is proteinuria, however, it can frequently progress to full nephrotic syndrome. Glucocorticosteroids are the first line of treatment and, in case of resistance, calcineurin inhibitors are used. In some patients, despite treatment, focal segmental glomerular sclerosis leads to end-stage renal disease, in which organ transplantation is the only therapeutic option. In several cases, relapse occurs in the transplanted organ. The following paper presents a case report of a patient treated for focal segmental glomerular sclerosis since the age of 21, who developed end-stage renal failure after seven years of disease despite immunosuppressive treatment. Although there was a significant risk of recurrence, it was decided to transplant a kidney from a family donor — the patient’s mother. From about one week after transplantation, progressive deterioration of graft function was observed.
Abstract
Focal segmental glomerular sclerosis is a pattern of histological damage of the kidney. The most common clinical manifestation is proteinuria, however, it can frequently progress to full nephrotic syndrome. Glucocorticosteroids are the first line of treatment and, in case of resistance, calcineurin inhibitors are used. In some patients, despite treatment, focal segmental glomerular sclerosis leads to end-stage renal disease, in which organ transplantation is the only therapeutic option. In several cases, relapse occurs in the transplanted organ. The following paper presents a case report of a patient treated for focal segmental glomerular sclerosis since the age of 21, who developed end-stage renal failure after seven years of disease despite immunosuppressive treatment. Although there was a significant risk of recurrence, it was decided to transplant a kidney from a family donor — the patient’s mother. From about one week after transplantation, progressive deterioration of graft function was observed.
Keywords
focal segmental glomerular sclerosis, graft loss, kidney transplantation
About this articleTitle
Graft loss from a living donor due to flash recurrence of focal segmental glomerular sclerosis — case report
Journal
Issue
Article type
Case report
Pages
317-319
Published online
2023-10-13
Page views
644
Article views/downloads
257
DOI
Bibliographic record
Medical Research Journal 2023;8(4):317-319.
Keywords
focal segmental glomerular sclerosis
graft loss
kidney transplantation
Authors
Marta Głuchowska
Łukasz Gawlik
Azita Razaei
Marcin Gregorczyk
Piotr Jagodowski
Paweł Wróbel
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