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Inflammation and hypoxia in atherosclerosis, coronary artery disease, and heart failure
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Abstract
Inflammation is a process that occurs after tissue damage or counteract infection. It is a complex reaction involving various cells, proteins (chemokines, acute-phase proteins) and other factors. The precise understanding of the mechanisms affecting the distribution of inflammatory cells and their modulators in areas of inflammation may have a crucial role in the development of strategies blocking inflammatory processes. Hypoxia leads to deprivation of oxygen and when it develops, various mechanisms come into action to alleviate any consequences that it might cause. Hypoxia inducible factor (HIF) is one of the most important factors involved in the response to hypoxia. Recent studies provide a better understanding of both, inflammation and hypoxia, in the development of atherosclerosis and various diseases in the spectrum of cardiology.
Abstract
Inflammation is a process that occurs after tissue damage or counteract infection. It is a complex reaction involving various cells, proteins (chemokines, acute-phase proteins) and other factors. The precise understanding of the mechanisms affecting the distribution of inflammatory cells and their modulators in areas of inflammation may have a crucial role in the development of strategies blocking inflammatory processes. Hypoxia leads to deprivation of oxygen and when it develops, various mechanisms come into action to alleviate any consequences that it might cause. Hypoxia inducible factor (HIF) is one of the most important factors involved in the response to hypoxia. Recent studies provide a better understanding of both, inflammation and hypoxia, in the development of atherosclerosis and various diseases in the spectrum of cardiology.
Keywords
inflammatory mediators, hypoxia, atherosclerosis
About this articleTitle
Inflammation and hypoxia in atherosclerosis, coronary artery disease, and heart failure
Journal
Issue
Article type
Review article
Pages
46-54
Published online
2015-07-14
Page views
668
Article views/downloads
2041
Bibliographic record
Folia Medica Copernicana 2015;3(2):46-54.
Keywords
inflammatory mediators
hypoxia
atherosclerosis
Authors
Łukasz Szylberg
Magdalena Bodnar
Jakub Michalski
Martyna Maciejewska
Andrzej Marszałek