open access

Vol 3, No 1 (2015)
REVIEW ARTICLES
Published online: 2015-03-31
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The clinical impact of assay standardization and traceability: A case study of cholesterol

Howard A. Morris
Folia Medica Copernicana 2015;3(1):1-6.

open access

Vol 3, No 1 (2015)
REVIEW ARTICLES
Published online: 2015-03-31

Abstract

Coronary heart disease (CHD) is the major cause of death internationally, and yet most can be prevented using population-wide strategies by addressing behavioral risk factors, including reduction of blood cholesterol levels. Following the definition of clinical decision limits for cholesterol according to risk of CHD, an international effort was undertaken to establish traceability of routine clinical cholesterol assays to improve reproducibility and accuracy. This task has been achieved through the establishment of the Cholesterol Reference Measurement Laboratory Network. This work is associated with a reduction in the number of persons with elevated cholesterol levels and reduction in the death rates from CHD. It has been a major achievement for the discipline of laboratory medicine and a guide for future efforts for the improvement of patient outcomes.

Abstract

Coronary heart disease (CHD) is the major cause of death internationally, and yet most can be prevented using population-wide strategies by addressing behavioral risk factors, including reduction of blood cholesterol levels. Following the definition of clinical decision limits for cholesterol according to risk of CHD, an international effort was undertaken to establish traceability of routine clinical cholesterol assays to improve reproducibility and accuracy. This task has been achieved through the establishment of the Cholesterol Reference Measurement Laboratory Network. This work is associated with a reduction in the number of persons with elevated cholesterol levels and reduction in the death rates from CHD. It has been a major achievement for the discipline of laboratory medicine and a guide for future efforts for the improvement of patient outcomes.
Get Citation

Keywords

traceability, cholesterol assays, cardiovascular disease, reference measurement procedures

About this article
Title

The clinical impact of assay standardization and traceability: A case study of cholesterol

Journal

Medical Research Journal

Issue

Vol 3, No 1 (2015)

Pages

1-6

Published online

2015-03-31

Bibliographic record

Folia Medica Copernicana 2015;3(1):1-6.

Keywords

traceability
cholesterol assays
cardiovascular disease
reference measurement procedures

Authors

Howard A. Morris

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