open access

Vol 3, No 1 (2015)
ORIGINAL ARTICLES
Published online: 2015-03-31
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Tissue factor and tissue factor pathway inhibitor in chronic obstructive pulmonary disease

Anna Szczypiorska, Małgorzata Czajkowska-Malinowska, Barbara Góralczyk, Liliana Bielis, Ewelina Drela, Krzysztof Góralczyk, Barbara Ruszkowska-Ciastek, Danuta Rość
Folia Medica Copernicana 2015;3(1):32-37.

open access

Vol 3, No 1 (2015)
ORIGINAL ARTICLES
Published online: 2015-03-31

Abstract

Background. The inflammatory process in patients with chronic obstructive pulmonary disease (COPD) interferes with the normal function of respiratory lung. There is strong evidence indicating that inflammatory process in patients with COPD may activate blood coagulation. However, little is known about the role of tissue factor (TF) pathway in the coagulation system activation in COPD.

Objectives. The aim of the study has been to evaluate the concentration of selected parameters of coagulation process, including TF and tissue factor pathway inhibitor (TFPI), in plasma of patients with COPD. Patients and methods. The study included 66 patients with COPD at different stages of disease according to GOLD 2006, mean age of 60.4 years. The control group consisted of 25 healthy volunteers (non-smokers). Total TF and TFPI concentrations and other haemostatic parameters were measured using Enzyme Linked Immunosorbent Assay (ELISA).

Results. Significantly higher concentrations of TF and TFPI (p = 0.03; p = 0.004, respectively) were observed in patients with COPD. The level of fibrinogen was also higher in the study group than in controls (p = 0.002). However, the activated partial thromboplastin time (aPTT) was shortened in COPD patients as compared with the control group (p = 0.0001).

Conclusion. The study showed that in patients suffering from COPD, the stimulation of the tissue factor- -dependent activation of coagulation is observed.

Abstract

Background. The inflammatory process in patients with chronic obstructive pulmonary disease (COPD) interferes with the normal function of respiratory lung. There is strong evidence indicating that inflammatory process in patients with COPD may activate blood coagulation. However, little is known about the role of tissue factor (TF) pathway in the coagulation system activation in COPD.

Objectives. The aim of the study has been to evaluate the concentration of selected parameters of coagulation process, including TF and tissue factor pathway inhibitor (TFPI), in plasma of patients with COPD. Patients and methods. The study included 66 patients with COPD at different stages of disease according to GOLD 2006, mean age of 60.4 years. The control group consisted of 25 healthy volunteers (non-smokers). Total TF and TFPI concentrations and other haemostatic parameters were measured using Enzyme Linked Immunosorbent Assay (ELISA).

Results. Significantly higher concentrations of TF and TFPI (p = 0.03; p = 0.004, respectively) were observed in patients with COPD. The level of fibrinogen was also higher in the study group than in controls (p = 0.002). However, the activated partial thromboplastin time (aPTT) was shortened in COPD patients as compared with the control group (p = 0.0001).

Conclusion. The study showed that in patients suffering from COPD, the stimulation of the tissue factor- -dependent activation of coagulation is observed.

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Keywords

COPD, inflammation, haemostasis, TF, TFPI

About this article
Title

Tissue factor and tissue factor pathway inhibitor in chronic obstructive pulmonary disease

Journal

Medical Research Journal

Issue

Vol 3, No 1 (2015)

Pages

32-37

Published online

2015-03-31

Bibliographic record

Folia Medica Copernicana 2015;3(1):32-37.

Keywords

COPD
inflammation
haemostasis
TF
TFPI

Authors

Anna Szczypiorska
Małgorzata Czajkowska-Malinowska
Barbara Góralczyk
Liliana Bielis
Ewelina Drela
Krzysztof Góralczyk
Barbara Ruszkowska-Ciastek
Danuta Rość

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