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25-hydroxyvitamin D insufficiency in children with newly diagnosed asthma
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Abstract
Background. 25-hydroxyvitamin D [25(OH)D] deficiency seems to be related to the development of asthma. Any evaluation of the relationship between asthma and 25(OH)D deficiency must consider the association between increased airway responsiveness, eosinophil counts and serum immunoglobulin E (IgE), and 25(OH)D as a potential player in airway remodelling.
Objective. We assessed the association of 25(OH)D with markers of atopy and eosinophilic inflammation in children with newly diagnosed asthma.
Methods. The study included 165 children aged 2–12 years. The diagnosis of asthma was performed by an experienced paediatric pulmonologist. Allergic asthma was diagnosed in 106 children, and non-allergic asthma in ten; in 49 children, asthma was excluded. Fasting blood was collected for cell counts, and serum was obtained to measure lipids, C-reactive protein (hsCRP), 25(OH)D and IgE.
Results. Children with asthma had significantly lower 25(OH)D (p < 0.001). Both groups had similar lipid values. Elevated total IgE concentration and eosinophil counts were found in asthmatics; neutrophils were similar in asthmatic and reference groups. There was a strong tendency to higher eosinophil counts in 25(OH)D-deficient children (< 20 ng/mL) with atopic asthma (p < 0.08).
Conclusion. In children with asthma, 25(OH)D insufficiency/deficiency is associated with higher eosinophil counts and IgE. 25(OH)D monitoring is important in the prevention and management of children with asthmaAbstract
Background. 25-hydroxyvitamin D [25(OH)D] deficiency seems to be related to the development of asthma. Any evaluation of the relationship between asthma and 25(OH)D deficiency must consider the association between increased airway responsiveness, eosinophil counts and serum immunoglobulin E (IgE), and 25(OH)D as a potential player in airway remodelling.
Objective. We assessed the association of 25(OH)D with markers of atopy and eosinophilic inflammation in children with newly diagnosed asthma.
Methods. The study included 165 children aged 2–12 years. The diagnosis of asthma was performed by an experienced paediatric pulmonologist. Allergic asthma was diagnosed in 106 children, and non-allergic asthma in ten; in 49 children, asthma was excluded. Fasting blood was collected for cell counts, and serum was obtained to measure lipids, C-reactive protein (hsCRP), 25(OH)D and IgE.
Results. Children with asthma had significantly lower 25(OH)D (p < 0.001). Both groups had similar lipid values. Elevated total IgE concentration and eosinophil counts were found in asthmatics; neutrophils were similar in asthmatic and reference groups. There was a strong tendency to higher eosinophil counts in 25(OH)D-deficient children (< 20 ng/mL) with atopic asthma (p < 0.08).
Conclusion. In children with asthma, 25(OH)D insufficiency/deficiency is associated with higher eosinophil counts and IgE. 25(OH)D monitoring is important in the prevention and management of children with asthmaKeywords
immunoglobulin E, 25-hydroxyvitamin D, eosinophils, asthma
About this articleTitle
25-hydroxyvitamin D insufficiency in children with newly diagnosed asthma
Journal
Issue
Article type
Original article
Pages
93-97
Published online
2014-12-16
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569
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1164
Bibliographic record
Folia Medica Copernicana 2014;2(3):93-97.
Keywords
immunoglobulin E
25-hydroxyvitamin D
eosinophils
asthma
Authors
Grażyna Odrowąż-Sypniewska
Gabriele Fulgheri
Joanna Siódmiak
Magdalena Krintus
Magdalena Kuligowska-Prusińska
Iwona Jaszowska
Radosława Staszak-Kowalska
Katarzyna Bergmann
Anna Zawadzka-Krajewska
Szymon Kierat
Urszula Demkow