A study to estimate the prevalence of Asymptomatic Bacteriuria (ASB) and identify risk factors and causative microorganisms relating to ASB and identify the microorganisms and their sensitivity pattern in type 2 diabetes mellitus (T2D)
Abstract
Introduction: The microbiological pattern and risk factors for asymptomatic bacteriuria (ASB), which is thought to occur before symptomatic urinary tract infections (UTI) in diabetes mellitus, vary by region. Data from India's eastern region is still missing, though.
Materials and methods: In order to (1) estimate the prevalence of ASB and its association with age, gender, duration of diabetes, and renal and glycemic status, and (2) identify the antibiotic sensitivity pattern of uropathogens and assess the utility of microbial pattern as a predictor of symptomatic UTI, a prospective longitudinal study involving 80 otherwise healthy type 2 diabetes patients with a one-year follow-up was conducted.
Results: In the present study, ASB was common in 21.25% of people with type 2 diabetes. The most frequent cause among males was found to be Klebsiella sp. It was discovered that having type 2 diabetes for a long time was the only risk factor for ASB. Age, gender, and recent glycemic status did not correlate. Patients with bacteriuria who had lower baseline HbA1C levels were more likely to get a UTI. Within a year, female diabetes patients with Escherichia coli-induced ASB were much more likely to get a UTI.
Conclusions: It will be truly unnecessary to reassess guidelines for screening for ASB caused by E. coli in females with chronic diabetes and poor glycemic control if a large-scale prospective trial replicates comparable results. In these patients, symptomatic UTI can be avoided by implementing a strict HbA1C reduction plan early on and taking steps to enhance genital hygiene.
Keywords: urinary tract infectiontype 2 diabetes mellitusasymptomatic bacteriuriaasymptomatic bacteriuria
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