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Published online: 2021-12-06
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SGLT2 inhibitors and the risk of urinary tract infections in patients with heart failure: A pooled analysis examining safety endpoints

Josip A Borovac12, Tina Kurir13, Ivona Mustapic2, Marko Kumric1, Josko Bozic1, Duska Glavas2, Domenico D’Amario4
DOI: 10.33963/KP.a2021.0172
·
Pubmed: 34870320
Affiliations
  1. Department of Pathophysiology, School of Medicine, University of Split, Split, Croatia
  2. Clinic for Heart and Vascular Diseases, University Hospital of Split, Split, Croatia
  3. Department of Endocrinology and Diabetology, University Hospital of Split, Split, Croatia
  4. Department of Cardiovascular and Thoracic Sciences, IRCCS Fondazione Policlinico A Gemelli, Universita Cattolica Sacro Cuore, Rome, Italy

open access

Online first
Short communication
Published online: 2021-12-06

Abstract

Not available

Abstract

Not available
Get Citation
About this article
Title

SGLT2 inhibitors and the risk of urinary tract infections in patients with heart failure: A pooled analysis examining safety endpoints

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Online first

Article type

Short communication

Published online

2021-12-06

DOI

10.33963/KP.a2021.0172

Pubmed

34870320

Authors

Josip A Borovac
Tina Kurir
Ivona Mustapic
Marko Kumric
Josko Bozic
Duska Glavas
Domenico D’Amario

References (13)
  1. de Leeuw AE, de Boer RA. Sodium-glucose cotransporter 2 inhibition: cardioprotection by treating diabetes-a translational viewpoint explaining its potential salutary effects. Eur Heart J Cardiovasc Pharmacother. 2016; 2(4): 244–255.
  2. Kluger AY, Tecson KM, Lee AY, et al. Class effects of SGLT2 inhibitors on cardiorenal outcomes. Cardiovasc Diabetol. 2019; 18(1): 99.
  3. Nessler J, Siniarski A, Leszek P, et al. Reviewers. Expert opinion of the Heart Failure Working Group of the Polish Cardiac Society on the use of dapagliflozin in the treatment of heart failure with reduced ejection fraction. Kardiol Pol. 2021; 79(3): 363–370.
  4. McMurray J, Solomon S, Inzucchi S, et al. Dapagliflozin in patients with heart failure and reduced ejection fraction. N Engl J Med. 2019; 381(21): 1995–2008.
  5. Anker SD, Butler J, Filippatos G, et al. Cardiovascular and renal outcomes with empagliflozin in heart failure. N Engl J Med. 2020; 383(15): 1413–1424.
  6. Kato ET, Silverman MG, Mosenzon O, et al. Effect of dapagliflozin on heart failure and mortality in type 2 diabetes mellitus. Circulation. 2019; 139(22): 2528–2536.
  7. Szarek M, Bhatt DL, Steg PhG, et al. Sotagliflozin in patients with diabetes and recent worsening heart failure. N Engl J Med. 2021; 384(2): 117–128.
  8. Butler J, Filippatos G, Siddiqi TJ, et al. Evaluation of the effects of sodium-glucose co-transporter 2 inhibition with empagliflozin on morbidity and mortality in patients with chronic heart failure and a preserved ejection fraction: rationale for and design of the EMPEROR-Preserved Trial. Eur J Heart Fail. 2019; 21(10): 1279–1287.
  9. Singh M, Kumar A. Risks associated with SGLT2 inhibitors: an overview. Curr Drug Saf. 2018; 13(2): 84–91.
  10. Bersoff-Matcha SJ, Chamberlain C, Cao C, et al. Fournier gangrene associated with sodium-glucose cotransporter-2 inhibitors: a review of spontaneous postmarketing cases. Ann Intern Med. 2019; 170(11): 764–769.
  11. Puckrin R, Saltiel MP, Reynier P, et al. SGLT-2 inhibitors and the risk of infections: a systematic review and meta-analysis of randomized controlled trials. Acta Diabetol. 2018; 55(5): 503–514.
  12. Dave CV, Schneeweiss S, Kim D, et al. Sodium-Glucose cotransporter-2 inhibitors and the risk for severe urinary tract infections: a population-based cohort study. Ann Intern Med. 2019; 171(4): 248–256.
  13. Higgins JPT, Altman DG, Gøtzsche PC, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011; 343: d5928.

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