open access

Vol 74, No 8 (2016)
Original articles
Published online: 2016-03-07
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Changes in flow-mediated dilatation in patients with femoropopliteal occlusion receiving conservative and invasive treatment

Katarzyna Pawlaczyk, Marcin Gabriel, Tomasz Urbanek, Łukasz Dzieciuchowicz, Beata Begier-Krasińska, Michał Stanisić, Krzysztof Wachal, Maciej Zieliński
DOI: 10.5603/KP.a2016.0027
·
Kardiol Pol 2016;74(8):772-778.

open access

Vol 74, No 8 (2016)
Original articles
Published online: 2016-03-07

Abstract

Background: Although the beneficial effect of revascularisation on reduction of local clinical ischaemic symptoms has been well established, its effect on systemic vascular endothelial function has not been fully explained yet.

Aim: To determine changes in endothelium-dependent flow-mediated dilatation in patients with unilateral femoropopliteal occlusion receiving medical and surgical treatment.

Methods: Seventy-nine patients with symptomatic atherosclerotic ischaemia of lower extremities, treated with endovascular procedures, with femoropopliteal graft, or receiving conservative treatment (21-day controlled treadmill training) were enrolled in the study. Ankle brachial pressure index (ABPI), skin blood flow on the feet, and flow-mediated dilatation (FMD) of brachial arteries were measured in each patient at baseline and after 90 days of follow-up.

Results: The ABPI, vasomotion in the myogenic frequency band, and FMD increased significantly in surgical patients. In patients after femoropopliteal bypass a significant increase of vasomotion in the endothelial frequency band was also observed. In patients receiving conservative treatment (treadmill training), vasomotion in the myogenic frequency band increased whereas the FMD remained unchanged.

Conclusions: It seems that surgical treatment may contribute to reducing the risk of cardiovascular complications in patients with advanced peripheral artery disease, as a result of improving the systemic vascular endothelial function. Limiting treatment to just treadmill training increases pain-free walking distance but does not improve systemic vascular endothelial function.

Abstract

Background: Although the beneficial effect of revascularisation on reduction of local clinical ischaemic symptoms has been well established, its effect on systemic vascular endothelial function has not been fully explained yet.

Aim: To determine changes in endothelium-dependent flow-mediated dilatation in patients with unilateral femoropopliteal occlusion receiving medical and surgical treatment.

Methods: Seventy-nine patients with symptomatic atherosclerotic ischaemia of lower extremities, treated with endovascular procedures, with femoropopliteal graft, or receiving conservative treatment (21-day controlled treadmill training) were enrolled in the study. Ankle brachial pressure index (ABPI), skin blood flow on the feet, and flow-mediated dilatation (FMD) of brachial arteries were measured in each patient at baseline and after 90 days of follow-up.

Results: The ABPI, vasomotion in the myogenic frequency band, and FMD increased significantly in surgical patients. In patients after femoropopliteal bypass a significant increase of vasomotion in the endothelial frequency band was also observed. In patients receiving conservative treatment (treadmill training), vasomotion in the myogenic frequency band increased whereas the FMD remained unchanged.

Conclusions: It seems that surgical treatment may contribute to reducing the risk of cardiovascular complications in patients with advanced peripheral artery disease, as a result of improving the systemic vascular endothelial function. Limiting treatment to just treadmill training increases pain-free walking distance but does not improve systemic vascular endothelial function.

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Keywords

endothelial flow-mediated dilatation, endothelial dysfunction, peripheral arterial occlusive disease, treadmill training, flowmotion

About this article
Title

Changes in flow-mediated dilatation in patients with femoropopliteal occlusion receiving conservative and invasive treatment

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 74, No 8 (2016)

Pages

772-778

Published online

2016-03-07

DOI

10.5603/KP.a2016.0027

Bibliographic record

Kardiol Pol 2016;74(8):772-778.

Keywords

endothelial flow-mediated dilatation
endothelial dysfunction
peripheral arterial occlusive disease
treadmill training
flowmotion

Authors

Katarzyna Pawlaczyk
Marcin Gabriel
Tomasz Urbanek
Łukasz Dzieciuchowicz
Beata Begier-Krasińska
Michał Stanisić
Krzysztof Wachal
Maciej Zieliński

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