open access

Vol 79, No 6 (2021)
Original article
Published online: 2021-03-30
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Use of T-wave duration and Tpeak-Tend interval as new prognostic markers for patients treated with cardiac resynchronization therapy

Songül Usalp, Ramazan Gündüz
DOI: 10.33963/KP.15919
·
Pubmed: 33825422
·
Kardiol Pol 2021;79(6):676-683.

open access

Vol 79, No 6 (2021)
Original article
Published online: 2021-03-30

Abstract

Background: The use of electrocardiography (ECG) is a practical method to evaluate the response to cardiac resynchronization therapy (CRT) implantation, as it is easily performed and saves time.
Aim: This study aimed to assess the predictive value of the T-wave duration and Tpeak-Tend (Tp-e) interval following the CRT implantation administered to heart failure patients.
Methods: Sixty-seven patients with left ventricular ejection fraction ≤35, New York Heart Association (NYHA) class II–III, ambulatory class IV, normal sinus rhythm, who have complete left bundle branch block on ECG and treated with CRT were included in this study. Patients who have manifested a ≥10% improvement in ejection fraction following CRT implantation, were categorized as “responders”, and the remaining patients were categorized as “non-responders”. ECGs and echocardiograms were evaluated both six months before and after CRT implantation.
Results: The post-CRT QRS duration (P = 0.01), cQT interval (P = 0.005), T-wave (P <0.001), and Tp-e interval (P <0.001) were found to be significantly reduced in the responder group compared to the non-responder group. The receiver operating characteristics curve analyses revealed that the predictive optimal cut-off of the T-wave was <182 ms (P <0.001), and that of the Tp-e interval was <92 ms (P <0.001).
Conclusions: T-wave and Tp-e interval may be independent predictors of a favorable CRT response in heart failure patients.

Abstract

Background: The use of electrocardiography (ECG) is a practical method to evaluate the response to cardiac resynchronization therapy (CRT) implantation, as it is easily performed and saves time.
Aim: This study aimed to assess the predictive value of the T-wave duration and Tpeak-Tend (Tp-e) interval following the CRT implantation administered to heart failure patients.
Methods: Sixty-seven patients with left ventricular ejection fraction ≤35, New York Heart Association (NYHA) class II–III, ambulatory class IV, normal sinus rhythm, who have complete left bundle branch block on ECG and treated with CRT were included in this study. Patients who have manifested a ≥10% improvement in ejection fraction following CRT implantation, were categorized as “responders”, and the remaining patients were categorized as “non-responders”. ECGs and echocardiograms were evaluated both six months before and after CRT implantation.
Results: The post-CRT QRS duration (P = 0.01), cQT interval (P = 0.005), T-wave (P <0.001), and Tp-e interval (P <0.001) were found to be significantly reduced in the responder group compared to the non-responder group. The receiver operating characteristics curve analyses revealed that the predictive optimal cut-off of the T-wave was <182 ms (P <0.001), and that of the Tp-e interval was <92 ms (P <0.001).
Conclusions: T-wave and Tp-e interval may be independent predictors of a favorable CRT response in heart failure patients.

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Keywords

cardiac resynchronization therapy, electrocardiography, heart failure, T-wave, Tpeak-Tend interval

About this article
Title

Use of T-wave duration and Tpeak-Tend interval as new prognostic markers for patients treated with cardiac resynchronization therapy

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 79, No 6 (2021)

Article type

Original article

Pages

676-683

Published online

2021-03-30

DOI

10.33963/KP.15919

Pubmed

33825422

Bibliographic record

Kardiol Pol 2021;79(6):676-683.

Keywords

cardiac resynchronization therapy
electrocardiography
heart failure
T-wave
Tpeak-Tend interval

Authors

Songül Usalp
Ramazan Gündüz

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