open access

Vol 79, No 10 (2021)
Original article
Published online: 2021-08-09
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The safety, efficacy, and cost-effectiveness of gentamycin-collagen sponge in multicomponent prevention strategy of cardiac implantable electronic device infections — a single-center experience

Krzysztof Kaczmarek1, Aleksander Strzelecki1, Paweł Ptaszyński1, Jerzy K Wranicz1, Iwona Cygankiewicz1
DOI: 10.33963/KP.a2021.0089
·
Pubmed: 34392518
·
Kardiol Pol 2021;79(10):1079-1085.
Affiliations
  1. Department of Electrocardiology, Medical University of Lodz, Łódź, Poland

open access

Vol 79, No 10 (2021)
Original article
Published online: 2021-08-09

Abstract

Background: Cardiac implantable electronic device (CIED) infections are associated with significant morbidity, mortality, and increased healthcare expenses. Apart from standard systemic antibiotic therapy, locally acting agents are under investigation as a potential approach for the prevention of this complication.
Aims: The study aimed to summarize our experience with a gentamycin-collagen sponge (GCS) in a multi-component prevention strategy of cardiac implantable electronic device infection.
Methods: We retrospectively analyzed medical records of 312 consecutive patients who underwent CIED-related surgery and had at least a 6-month follow-up. All the individuals had GCS applied during surgery. An incidence of CIEDs-related infection in our group was compared to the risk level calculated according to the commonly used scores. Analysis of cost-effectiveness was also performed.
Results: Incidence of CIED-related infection, defined as a primary endpoint, occurred relatively rarely (0.33%) as compared to the infection risk calculated according to commonly used scores Prevention of Arrythmia Device Infection Trial (PADIT) — 0.83%; CIED-AI — 0.90% or Mittal score — 1.00%; P <0.001 — for all). We did not record any complications related to GCS. We analyzed the cost-effectiveness of our GCS-based approach, which appeared to be financially beneficial (number needed to treat 149–200; difference of CIED infection treatment cost and GCSs price was 5093–26525 $).
Conclusions: We conclude that: (1) the use of GCS to reduce CIEDs infections is feasible and safe;  (2) our multicomponent prevention strategy involving the GCS application seems to significantly reduce the rate of CIED infection, and it is cost-effective.

Abstract

Background: Cardiac implantable electronic device (CIED) infections are associated with significant morbidity, mortality, and increased healthcare expenses. Apart from standard systemic antibiotic therapy, locally acting agents are under investigation as a potential approach for the prevention of this complication.
Aims: The study aimed to summarize our experience with a gentamycin-collagen sponge (GCS) in a multi-component prevention strategy of cardiac implantable electronic device infection.
Methods: We retrospectively analyzed medical records of 312 consecutive patients who underwent CIED-related surgery and had at least a 6-month follow-up. All the individuals had GCS applied during surgery. An incidence of CIEDs-related infection in our group was compared to the risk level calculated according to the commonly used scores. Analysis of cost-effectiveness was also performed.
Results: Incidence of CIED-related infection, defined as a primary endpoint, occurred relatively rarely (0.33%) as compared to the infection risk calculated according to commonly used scores Prevention of Arrythmia Device Infection Trial (PADIT) — 0.83%; CIED-AI — 0.90% or Mittal score — 1.00%; P <0.001 — for all). We did not record any complications related to GCS. We analyzed the cost-effectiveness of our GCS-based approach, which appeared to be financially beneficial (number needed to treat 149–200; difference of CIED infection treatment cost and GCSs price was 5093–26525 $).
Conclusions: We conclude that: (1) the use of GCS to reduce CIEDs infections is feasible and safe;  (2) our multicomponent prevention strategy involving the GCS application seems to significantly reduce the rate of CIED infection, and it is cost-effective.

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Keywords

antibiotic prophylaxis, cardiac implantable electronic device, gentamycin-collagen sponge, infection

About this article
Title

The safety, efficacy, and cost-effectiveness of gentamycin-collagen sponge in multicomponent prevention strategy of cardiac implantable electronic device infections — a single-center experience

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 79, No 10 (2021)

Article type

Original article

Pages

1079-1085

Published online

2021-08-09

DOI

10.33963/KP.a2021.0089

Pubmed

34392518

Bibliographic record

Kardiol Pol 2021;79(10):1079-1085.

Keywords

antibiotic prophylaxis
cardiac implantable electronic device
gentamycin-collagen sponge
infection

Authors

Krzysztof Kaczmarek
Aleksander Strzelecki
Paweł Ptaszyński
Jerzy K Wranicz
Iwona Cygankiewicz

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