Vol 68, Supp. V (2010)
Reviews
Published online: 2010-11-25
Overview on omega-3 polyunsaturated fatty acids and heart failure
DOI: 10.33963/v.kp.79578
Abstract
Despite aggressive pharmacotherapy, heart failure is still clinical problem. Current therapies improve clinical symptoms and
slow progression to heart failure, but overall the prognosis remains poor. Evidence from epidemiological, clinical and experimental
studies indicates a beneficial role of the omega-3 polyunsaturated fatty acids (omega-3 PUFA) found in fish oils in the
prevention and management of heart failure. Although the mechanisms is still unclear, clinical and animals studies indicate
that the benefits of omega-3 PUFA may be attributed to a number of distinct biological effects on lipoprotein metabolism,
inflammation response and mitochondrial function. This review summarise the data related to use of omega-3 PUFA supplementation
as a potential treatment for heart failure and discussed possible mechanism of action.
Kardiol Pol 2010; 68, supl. V: 400-404
Kardiol Pol 2010; 68, supl. V: 400-404
Keywords: heart failurelipoproteinsinflammationmitochondriaomega-3 polyunsaturated fatty acids