Vol 69, Supp. III (2011)
Reviews
Published online: 2011-11-24
Physical training as an effective way to protect the heart against ischaemia
DOI: 10.33963/v.kp.79153
Abstract
The findings from experimental animal studies show that regular physical trainings can protect via preconditioning the heart
against the ischaemia-reperfusion (IR) injury. It is not clear if the cellular mechanism is the same as in the case of ischaemic
preconditioning, but the final effect is the same, i.e. a stress stimulus, in this case a repeated effort leaves the heart with the
‘memory’, which translates into an increased resistance to ischaemia. At present, the precise mechanism responsible for
training-induced cardioprotection is not clear. Candidate factors responsible for this cardioprotection are numerous and
include collateral circulation development, enhanced ER stress proteins, increased COX-2 activity, increased heat shock
protein (HSP-72) levels, increased activity of mitoK-ATP and sarcoK-ATP channels, and increased myocardial antioxidative
capacity. The studies performed so far have suggested that MnSOD activity and increased sarcoK-ATP expression did play
a role in exercise-induced cardioprotection. There may exist some other mechanisms responsible for this type of cardioprotection,
but finding them will be possible only through further relevant studies. The paper presents the up-to-date knowledge
in this field.
Kardiol Pol 2011; 69, supl. III: 75–79
Kardiol Pol 2011; 69, supl. III: 75–79
Keywords: exercise-induced myocardial preconditioningmechanisms of exercise-induced preconditioning