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Vol 15, No 1 (2022)
Case report
Published online: 2022-04-07

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Acquired hemophilia A secondary to rheumatoid arthritis

Alan Majeranowski12, Filip Lebiedziński3, Izabela Topolewska4, Aleksandra Cegła3, Damian Palus5, Jakub Osowski3, Andrzej Mital1
Journal of Transfusion Medicine 2022;15(1):57-59.

Abstract

Acquired hemophilia A (AHA) is a rare plasma diathesis. Unlike congenital hemophilia A, AHA occurs in both sexes and the incidence of the disease increases with age. It is caused by the production of autoantibodies against the coagulation factor VIII. AHA can be primary or secondary. The clinical course is characterized by a rapid development of symptoms, massive bleeding and high mortality. In the described case, a 69-year-old female was successfully treated for severe AHA with bypass-concentrate — recombinant activated factor VII and immunosuppressive therapy.

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Journal of Transfusion Medicine