A 34-year-old otherwise healthy immunocompetent woman, was seen 2 weeks after coming back from a 3-month stay in a small village located in Tanzania, where she participated in a volunteer humanitarian programme. The patient presented with watery, foul-smelling diarrhoea, associated with asthenia, dyspepsia, abdominal cramps/pain, mild arthralgia predominantly involving the upper and lower limbs, and a diffuse symmetric pompho-erythemato-petechial cutaneous vasculitis-like rash initially localized on the buttocks and trunk, and later spreading to the upper and lower limbs, characterised by small non-itching but palpable papules (Fig. 1). After skin biopsy, histopathologic studies confirmed IgA vasculitis. The patient denied contact with water from uncontrolled sources; however, during her stay in Africa, the patient worked as a health care professional and had contact with paediatric patients. Also, the patient reported having unprotected sex while in Africa. Before leaving Italy for Africa, the patient had been immunised against hepatitis A, typhoid fever and yellow fever, and received antimalarial prophylaxis as well.
Figure 1. Lambliasis-associated Schönlein-Henoch purpura
Laboratory examinations showed that a platelet count and coagulation tests results were within normal limits. The tests demonstrated mild leukocytosis and eosinophilia (12.000 and 900 cells/µL, respectively). Microhaematuria and mild albuminuria, together with mild serum aspartate aminotransferase (AST/GOT, 110 U/L, normal value: 5–50) and alanine aminotransferase (ALT/GPT, 160 U/L, normal value: 5–50) indicated limited but present kidney and liver involvement, respectively. Serum C2-C3 complement fraction consumption and moderately reduced serum IgA levels were fully consistent with the diagnosis of Schönlein-Henoch purpura (SHP). As for the microbiological tests results, all cultures for bacteria, mycobacteria and fungi tested negative, as well as all serological examinations for bacterial or viral diseases, malaria tests, and all parasite tests performed on blood/urine/stool specimens, when trying to detect Giardia lamblia by both direct methods and DNA immunoenzymatic assay on multiple consecutive stool specimens. The typical clinical and laboratory picture associated with parasitological findings confirmed the diagnosis. The administration of a full dose of oral tinidazole, and of an oral probiotic including Lactobacillus reuteri and vitamin D, plus supportive rehydration therapy led to a complete resolution of signs and symptoms, with negative stool test results within 3 weeks of treatment. Follow-up tests performed 3 months and again 6 months post treatment revealed no abnormalities.
Schönlein-Henoch purpura is a form of vasculitis which is common in children, but is rare among adults. Typical manifestations include palpable purpura, abdominal pain, arthritis, and haematuria. It frequently occurs following an infectious trigger and involves IgA and C3 deposition in the walls of the small vessels. Many infectious agents were proposed as a potential trigger for SHP, particularly B-haemolytic Streptococci. Other bacterial agents that have been suggested as possible triggers of SHP include Salmonella, Mycoplasma pneumonia, Staphylococcus aureus, Helicobacter pylori and Bartonella henselae [1–11]. Many reports suggest that several viruses and vaccine inoculations should be included in the list of differentials responsible for triggering SHP. SHP, however, is rarely reported in association with parasitic infections [1–11]. Only 43 cases of SHP in association with parasites have been found in a MEDLINE search; they are summarised in Table 1 [1–11]. The analysis of the data retrieved suggests that, although it is an infrequent combination, clinicians should not underestimate this possibility. Parasitic diseases less frequently reported as triggers of SHP include intestinal giardiasis, amoebiasis, and toxocariasis. It was frequently responsible for the development of SHP nephritis in the cases described. Although representing an extremely rare condition, which was proved by our literature search [1–11], clinicians should be aware of the infrequent, but possible role of giardiasis in prompting SHP at any age and in the absence of underlying comorbidities.
References, year, country |
Patient, age/ |
Parasitic infection |
Kidney disease |
Treatment |
Clinical course |
Janković et al., 2016, Serbia |
A 14-year-old girl |
Strongyloides stercoralis |
HSP nephritis |
Mebendazole; prednisone + azathioprine + enalapril |
Recovery |
Tutanç et al., 2013, Turkey |
A 30-month-boy |
Blastocystis hominis |
Renal function tests remained normal |
Systemic steroid |
Recovery |
Thapa et al., 2010, India |
A 9-year-old otherwise |
Plasmodium falciparum, |
Renal function tests remained normal |
Parenteral artesunate. |
Recovery |
Hamidou et al., 1999, France |
A 17-year-old boy |
Toxocara canis infection |
Renal function tests remained normal |
No anthelmintic treatment |
Recovery |
Bellanger et al., 2011, Canada |
A 28-year-old woman |
Toxocara canis infection |
HSP nephritis |
An anthelmintic treatment with diethylcarbamazine together with the corticosteroid treatment |
Recovery |
Ergür et al., |
35 cases of HSP (25 males, 10 females), aged between 2 and 15 years |
Giardia intestinalis 14 cases, Trichomonas hominis 6 cases, Entamoeba histolytica 3 cases, Ascaris lumbricoides 2 cases |
Renal involvement 8 cases |
NR |
NR |
Kim et al., 2010, Korea |
An 8-year-old girl |
Entamoeba histolytica |
Renal function tests remained normal |
Empirical antibiotic (metronidazole), methylprednisolone /oral prednisolone |
Recovery |
Demiricin et al., 1998, Turkey |
An 11-year-old boy |
Entamoeba histolytica |
HSP nephritis |
Metronidazole, prednisolone |
Recovery |
Reitano, Fondacaro, 1950, Italy |
Data not available |
Ascarids |
Data not available |
Data not available |
Data not available |