Successful nilotinib cessation after imatinib therapy intolerance
Abstract
Taking into consideration the high efficacy of tyrosine kinase inhibitors (TKI) in the therapy of chronic myelogenous leukemia (CML) in the chronic phase, high quality of patients life is becoming a more and more important therapeutic goal reachable by limiting treatment toxicity and, optimally, obtaining treatment-free remission (TFR). This can be achieved by effective management TKIs side effects and ultimately by stopping TKI in patients who achieved a deep molecular response (DMR). Here, we present a patient with CML, who was switched to nilotinib due to imatinib intolerance. Despite very good subjective nilotinib tolerance, hyperlipidemia and hyperglycemia occurred. After a few years of sustained DMR nilotinib was discontinued. Almost one year since this decision, the patient has remained in the TFR.
Keywords: CMLTKInilotinibtreatment-free remission
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