Advanced search

Vol 11, No 1 (2020)
Review paper
Published online: 2020-06-30

open access

View PDF (Polish) Download PDF file
Page views 1070
Article views/downloads 399
Get Citation

Connect on Social Media

Connect on Social Media

Will the use of autologous blood derivatives be the gold standard in various medicine specialties in the 21st century?

Jacek Nowak1, Marcin Adamiec2, Bartłomiej Iwańczyk3, Maciej Czerniuk1
DOI: 10.5603/Hem.2020.0002
Hematologia 2020;11(1):22-29.

Abstract

Due to the positive effect of the use of platelet concentrates, blood derivatives are currently used in many medical specialties. Platelet rich plasma was the first generation of this autogenic material and has been most commonly used so far. The exceptions were the fields of dentistry – oral and maxillofacial surgery, periodontics and implant surgery, where platelet rich fibrin (Platelet Rich Fibrin, PRF) was more widely. However, a changing trend is also visible in other fields of medicine, where PRF is becoming more important. The reason for the use of platelet concentrates and the ability to match their type to a specific surgical procedure is extremely important because of the different physico-chemical and biological properties. This article will introduce the use of autologous blood derivatives. The multitude of potential applications in medicine proves versatility, minimal risk of complications associated with the use of platelet concentrates, and above all - improvement of all parameters related to healing, tissue regeneration or prevention of complications after surgery. Undoubtedly, the scope of indications for the use of these preparations will increase, and the protocols for their preparation will be improved.

Keywords: Autologous blood derivativesplatelet rich fibrinplatelet rich plasmaimplantologyorthopaedicsophthalmologyaesthetic medicine

Article available in PDF format

View PDF (Polish) Download PDF file

References

  1. Jameson CA. Autologous platelet concentrate for the production of platelet gel. Laboratory Medicine. 2007; 38(1): 39–42.
    CrossRef
  2. Whitman DH, Berry R, Green D. Platelet gel: an autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg. 1997; 55(11): 1294–1299.
    CrossRef
  3. Nugraha HK, Muljanti M, Hernaningsih Y, et al. Platelet rich plasma preparation protocols: a preliminary study. Infect Dis Trop Med. 2012; 3(2): 104–107.
    CrossRef
  4. Chmielewska MCK, Iwańczyk B, Wojtowicz A. Możliwości zastosowania PRP i PRF w sterowanej regeneracji tkanek w chirurgii stomatologicznej. Dental Tribune 2014. https://pl.dental-tribune.com/news/mozliwosci-zastosowania-prp-i-prf-w-sterowanej-regeneracji-tkanek-w-chirurgii-stomatologicznej/ (February 3, 2020).
  5. Choukroun J, Diss A, Simonpieri A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101(3): 299–303.
    CrossRefPubMed
  6. Choukroun J, Diss A, Simonpieri A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101(3): e56–e60.
    CrossRefPubMed
  7. Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101(3): e45–e50.
    CrossRefPubMed
  8. Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101(3): e51–e55.
    CrossRefPubMed
  9. Su CY, Kuo YaPo, Tseng YuH, et al. In vitro release of growth factors from platelet-rich fibrin (PRF): a proposal to optimize the clinical applications of PRF. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009; 108(1): 56–61.
    CrossRefPubMed
  10. Dohan Ehrenfest DM, de Peppo GM, Doglioli P, et al. Slow release of growth factors and thrombospondin-1 in Choukroun's platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors. 2009; 27(1): 63–69.
    CrossRefPubMed
  11. Dohan Ehrenfest DM, Bielecki T, Jimbo R, et al. Do the fibrin architecture and leukocyte content influence the growth factor release of platelet concentrates? An evidence-based answer comparing a pure platelet-rich plasma (P-PRP) gel and a leukocyte- and platelet-rich fibrin (L-PRF). Curr Pharm Biotechnol. 2012; 13(7): 1145–1152.
    CrossRefPubMed
  12. Kang YH, Jeon SH, Park JY, et al. Platelet-rich fibrin is a Bioscaffold and reservoir of growth factors for tissue regeneration. Tissue Eng Part A. 2011; 17(3-4): 349–359.
    CrossRefPubMed
  13. Lundquist R, Dziegiel MH, Agren MS. Bioactivity and stability of endogenous fibrogenic factors in platelet-rich fibrin. Wound Repair Regen. 2008; 16(3): 356–363.
    CrossRefPubMed
  14. Kobayashi E, Flückiger L, Fujioka-Kobayashi M, et al. Comparative release of growth factors from PRP, PRF, and advanced-PRF. Clin Oral Investig. 2016; 20(9): 2353–2360.
    CrossRefPubMed
  15. Nishimoto S, Fujita K, Sotsuka Y, et al. Growth factor measurement and histological analysis in platelet rich fibrin: a pilot study. J Maxillofac Oral Surg. 2015; 14(4): 907–913.
    CrossRefPubMed
  16. Takeda Y, Katsutoshi K, Matsuzaka K, et al. The effect of concentrated growth factor on rat bone marrow cells in vitro and on calvarial bone healing in vivo. Int J Oral Maxillofac Implants. 2015; 30(5): 1187–1196.
    CrossRefPubMed
  17. Masuki H, Okudera T, Watanebe T, et al. Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF), and concentrated growth factors (CGF). Int J Implant Dent. 2016; 2(1): 19.
    CrossRefPubMed
  18. Dohan Ehrenfest DM, Diss A, Odin G, et al. In vitro effects of Choukroun's PRF (platelet-rich fibrin) on human gingival fibroblasts, dermal prekeratinocytes, preadipocytes, and maxillofacial osteoblasts in primary cultures. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009; 108(3): 341–352.
    CrossRefPubMed
  19. He L, Lin Ye, Hu X, et al. A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009; 108(5): 707–713.
    CrossRefPubMed
  20. Kobayashi E, Flückiger L, Fujioka-Kobayashi M, et al. Comparative release of growth factors from PRP, PRF, and advanced-PRF. Clin Oral Investig. 2016; 20(9): 2353–2360.
    CrossRefPubMed
  21. Giannini S, Cielo A, Bonanome L, et al. Comparison between PRP, PRGF and PRF: lights and shadows in three similar but different protocols. Eur Rev Med Pharmacol Sci. 2015; 19(6): 927–930.
    PubMed
  22. Murray PE. Platelet-rich plasma and patelet-rich fibrin can induce apical closure more frequently than blood-clot revascularization for the regeneration of immature permanent teeth: a meta-analysis of clinical efficacy. Front Bioeng Biotechnol. 2018; 6: 139.
    CrossRefPubMed
  23. Ulusoy AT, Turedi I, Cimen M, et al. Evaluation of blood clot, platelet-rich plasma, platelet-rich fibrin, and platelet pellet as scaffolds in regenerative endodontic treatment: a prospective randomized trial. J Endod. 2019; 45(5): 560–566.
    CrossRefPubMed
  24. Patidar S, Kalra N, Khatri A, et al. Clinical and radiographic comparison of platelet-rich fibrin and mineral trioxide aggregate as pulpotomy agents in primary molars. J Indian Soc Pedod Prev Dent. 2017; 35(4): 367–373.
    CrossRefPubMed
  25. Nageh M, Ahmed GM, El-Baz AA. Assessment of regaining pulp sensibility in mature necrotic teeth using a modified revascularization technique with platelet-rich fibrin: a clinical study. J Endod. 2018; 44(10): 1526–1533.
    CrossRefPubMed
  26. Zhou R, Wang Y, Chen Y, et al. Radiographic, hstologic, and biomechanical evaluation of combined application of platelet-rich fibrin with blood clot in regenerative endodontics. J Endod. 2017; 43(12): 2034–2040.
    CrossRefPubMed
  27. Singh S, Singh A, Singh S, et al. Application of PRF in surgical management of periapical lesions. Natl J Maxillofac Surg. 2013; 4(1): 94–99.
    CrossRefPubMed
  28. Bambal D, Manwar NU, Chandak M, et al. A comparative evaluation of the healing ability of bilateral periapical lesions treated with and without the use of platelet-rich fibrin. Todays FDA. 2012; 24(6): 54–57.
    PubMed
  29. Romesh SAP, Himanshi Y, Nitesh M, et al. Bone augmentation with sticky bone and platelet-rich fibrin by ridge-split technique and nasal floor engagement for immediate loading of dental implant after extracting impacted canine. Natl J Maxillofac Surg. 2019; 10(1): 98–101.
    CrossRefPubMed
  30. Aprajita B. Guided bone regeneration using a platelet-rich fibrin membrane and sticky bone graft along with implant placement in maxillary anterior region: a case report. J Adv Med Dental Sci Res. 2018; 6(5): 2.
  31. Toffler M. Guided bone regeneration (GBR) using cortical bone pins in combination with leukocyte- and platelet-rich fibrin (L-PRF). Compend Contin Educ Dent. 2014; 35(3): 192–198.
    PubMed
  32. Cortese A, Pantaleo G, Amato M, et al. Platelet-rich fbrin (PRF) in implants dentistry in combination with new bone regenerative fapless technique: evolution of the technique and final results. Open Med (Wars). 2017; 12: 24–32.
    CrossRefPubMed
  33. Toffler M, Toscano N, Holtzclaw D. Osteotome-mediated sinus floor elevation using only platelet-rich fibrin: an early report on 110 patients. Implant Dent. 2010; 19(5): 447–456.
    CrossRefPubMed
  34. Tajima N, Ohba S, Sawase T, et al. Evaluation of sinus floor augmentation with simultaneous implant placement using platelet-rich fibrin as sole grafting material. Int J Oral Maxillofac Implants. 2013; 28(1): 77–83.
    CrossRefPubMed
  35. Öncü E, Kaymaz E. Assessment of the effectiveness of platelet rich fibrin in the treatment of Schneiderian membrane perforation. Clin Implant Dent Relat Res. 2017; 19(6): 1009–1014.
    CrossRefPubMed
  36. Al-Juboori MJ, Al-Attas MA, Magno Filho LC. Treatment of chronic oroantral fistula with platelet-rich fibrin clot and collagen membrane: a case report. Clin Cosmet Investig Dent. 2018; 10: 245–249.
    CrossRefPubMed
  37. Hancı M, Karamese M, Tosun Z, et al. Intra-articular platelet-rich plasma injection for the treatment of temporomandibular disorders and a comparison with arthrocentesis. J Craniomaxillofac Surg. 2015; 43(1): 162–166.
    CrossRefPubMed
  38. Albilia JB, Herrera-Vizcaino C, Weisleder H, et al. Liquid platelet-rich fibrin injections as a treatment adjunct for painful temporomandibular joints: preliminary results. Cranio. 2018 [Epub ahead of print]: 1–13.
    CrossRefPubMed
  39. Rasmussen J, Ruggeri C, Ciraolo C, et al. Application of fibrin rich in leukocytes and platelets in the reconstruction of endoscopic approaches to the skull base. World Neurosurg. 2018; 118: 32–41.
    CrossRefPubMed
  40. Elkahwagi M, Elokda M, Elghannam D, et al. Role of autologous platelet-rich fibrin in relocation pharyngoplasty for obstructive sleep apnoea. Int J Oral Maxillofac Surg. 2020; 49(2): 200–206.
    CrossRefPubMed
  41. Garin P, Mullier F, Gheldof D, et al. Platelet-rich fibrin (PRF): an autologous packing material for middle ear microsurgery. B-ENT. 2014; 10(1): 27–34.
    PubMed
  42. Ehrenfest DMD, Andia I, Zumstein MA, et al. Classification of platelet concentrates (patelet-rich plasma-PRP, platelet-rich fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscle Ligaments and Tendons Journal. 2019; 04(01): 03.
    CrossRef
  43. Alviti F, Gurzì M, Santilli V, et al. Achilles tendon open surgical treatment with platelet-rich fibrin matrix augmentation: biomechanical evaluation. J Foot Ankle Surg. 2017; 56(3): 581–585.
    CrossRefPubMed
  44. Dietrich F, L Duré G, P Klein C, et al. Platelet-rich fibrin promotes an accelerated healing of Achilles tendon when compared to platelet-rich plasma in rat. World J Plast Surg. 2015; 4(2): 101–109.
    PubMed
  45. Antuña S, Barco R, Martínez Diez JM, et al. Platelet-rich fibrin in arthroscopic repair of massive rotator cuff tears: a prospective randomized pilot clinical trial. Acta Orthop Belg. 2013; 79(1): 25–30.
    PubMed
  46. Hurley ET, Lim Fat D, Moran CJ, et al. The efficacy of platelet-rich plasma and platelet-rich fibrin in arthroscopic rotator cuff repair: a meta-analysis of randomized controlled trials. Am J Sports Med. 2019; 47(3): 753–761.
    CrossRefPubMed
  47. Mao XH, Zhan YJ. The efficacy and safety of platelet-rich fibrin for rotator cuff tears: a meta-analysis. J Orthop Surg Res. 2018; 13(1): 202.
    CrossRefPubMed
  48. Grecu AF, Reclaru L, Ardelean LC, et al. Platelet-rich fibrin and its emerging therapeutic benefits for musculoskeletal injury treatment. Medicina (Kaunas). 2019; 55(5).
    CrossRefPubMed
  49. Chien CS, Ho HO, Liang YC, et al. Incorporation of exudates of human platelet-rich fibrin gel in biodegradable fibrin scaffolds for tissue engineering of cartilage. J Biomed Mater Res B Appl Biomater. 2012; 100(4): 948–955.
    CrossRefPubMed
  50. Cieslik-Bielecka A, Choukroun J, Odin G, et al. L-PRP/L-PRF in esthetic plastic surgery, regenerative medicine of the skin and chronic wounds. Curr Pharm Biotechnol. 2012; 13(7): 1266–1277.
    CrossRefPubMed
  51. Crisci A, Marotta G, Licito A, et al. Use of leukocyte platelet (L-PRF) rich fibrin in diabetic foot ulcer with osteomyelitis (three clinical cases report). Diseases. 2018; 6(2).
    CrossRefPubMed
  52. Tsai HC, Chang GRL, Fan HC, et al. A mini-pig model for evaluating the efficacy of autologous platelet patches on induced acute full thickness wound healing. BMC Vet Res. 2019; 15(1): 191.
    CrossRefPubMed
  53. Zhang S, Cao D, Xie J, et al. Platelet-rich fibrin as an alternative adjunct to tendon-exposed wound healing: A randomized controlled clinical trial. Burns. 2019; 45(5): 1152–1157.
    CrossRefPubMed
  54. Yu Y, Shen J, Fang G, et al. Use of autologous platelet rich fibrin-based bioactive membrane in pressure ulcer healing in rats. J Wound Care. 2019; 28(Sup4): S23–S30.
    CrossRefPubMed
  55. Pinto NR, Ubilla M, Zamora Y, et al. Leucocyte- and platelet-rich fibrin (L-PRF) as a regenerative medicine strategy for the treatment of refractory leg ulcers: a prospective cohort study. Platelets. 2018; 29(5): 468–475.
    CrossRefPubMed
  56. Passaretti F, Tia M, D'Esposito V, et al. Growth-promoting action and growth factor release by different platelet derivatives. Platelets. 2014; 25(4): 252–256.
    CrossRefPubMed
  57. Alser OH, Goutos I. The evidence behind the use of platelet-rich plasma (PRP) in scar management: a literature review. Scars Burn Heal. 2018; 4: 2059513118808773.
    CrossRefPubMed
  58. Elghblawi E. Platelet-rich plasma, the ultimate secret for youthful skin elixir and hair growth triggering. J Cosmet Dermatol. 2018; 17(3): 423–430.
    CrossRefPubMed
  59. Gawdat HI, Tawdy AM, Hegazy RA, et al. Autologous platelet-rich plasma versus readymade growth factors in skin rejuvenation: A split face study. J Cosmet Dermatol. 2017; 16(2): 258–264.
    CrossRefPubMed
  60. Ariyati N, Handono K, Nurdiana N, et al. What is the best degree of hyaluronic acid crosslinking in increasing growth factors level of platelet-rich fibrin lysate? J Stem Cells Regen Med. 2019; 15(1): 3–7.
    PubMed
  61. Qu Q, Shi P, Yi Y, et al. Efficacy of platelet-rich plasma for treating androgenic alopecia of varying grades. Clin Drug Investig. 2019; 39(9): 865–872.
    CrossRefPubMed
  62. Mao G, Zhang G, Fan W. Platelet-rich plasma for treating androgenic alopecia: a systematic review. Aesthetic Plast Surg. 2019; 43(5): 1326–1336.
    CrossRefPubMed
  63. Lotti T, Goren A, Verner I, et al. Platelet rich plasma in androgenetic alopecia: a systematic review. Dermatol Ther. 2019; 32(3): e12837.
    CrossRefPubMed
  64. Khademi F, Tehranchinia Z, Abdollahimajd F, et al. The effect of platelet rich plasma on hair regrowth in patients with alopecia areata totalis: A clinical pilot study. Dermatol Ther. 2019; 32(4): e12989.
    CrossRefPubMed
  65. Orliac S, Serfaty JM, Perozziello A, et al. Efficacy of subcutaneous injection of platelet-rich plasma in alopecia: a clinical and histological pilot study on a rat model with a six-month long-term follow-up experience. J Cosmet Dermatol. 2018; 17(2): 214–219.
    CrossRefPubMed
  66. Keyhan SO, Hemmat S, Badri AA, et al. Use of platelet-rich fibrin and platelet-rich plasma in combination with fat graft: which is more effective during facial lipostructure? J Oral Maxillofac Surg. 2013; 71(3): 610–621.
    CrossRefPubMed
  67. Gorlero F, Glorio M, Lorenzi P, et al. New approach in vaginal prolapse repair: mini-invasive surgery associated with application of platelet-rich fibrin. Int Urogynecol J. 2012; 23(6): 715–722.
    CrossRefPubMed
  68. Soyer T, Ayva Ş, Boybeyi Ö, et al. The effect of platelet rich fibrin on growth factor levels in urethral repair. J Pediatr Surg. 2013; 48(12): 2545–2549.
    CrossRefPubMed
  69. Soyer T, Çakmak M, Aslan MK, et al. Use of autologous platelet rich fibrin in urethracutaneous fistula repair: preliminary report. Int Wound J. 2013; 10(3): 345–347.
    CrossRefPubMed
  70. Cakmak HB, Dereli Can G, Can ME, et al. A novel graft option after pterygium excision: platelet-rich fibrin for conjunctivoplasty. Eye (Lond). 2017; 31(11): 1606–1612.
    CrossRefPubMed
  71. Can ME, Dereli Can G, Cagil N, et al. Urgent therapeutic grafting of platelet-rich fibrin membrane in descemetocele. Cornea. 2016; 35(9): 1245–1249.
    CrossRefPubMed
  72. Sun CK, Zhen YY, Leu S, et al. Direct implantation versus platelet-rich fibrin-embedded adipose-derived mesenchymal stem cells in treating rat acute myocardial infarction. Int J Cardiol. 2014; 173(3): 410–423.
    CrossRefPubMed
  73. Chen YL, Sun CK, Tsai TH, et al. Adipose-derived mesenchymal stem cells embedded in platelet-rich fibrin scaffolds promote angiogenesis, preserve heart function, and reduce left ventricular remodeling in rat acute myocardial infarction. Am J Transl Res. 2015; 7(5): 781–803.
    PubMed

About cookies

Necessary cookies

Allways active

These cookies are necessary for the proper display and operation of the website. Blocking them may cause the website to malfunction.

Analytical cookies

As part of our website, we use analytical tools, such as Google Analytics, that allow us to verify website traffic. These tools may require the use of cookies.

Community cookies

These are cookies associated with the social networks we use. Accepting them will allow us to associate your visit to the site with our social media profiles.

Marketing cookies

These are cookies responsible for carrying out advertising and marketing activities - consenting to their use will allow us to target you with advertisements based on your previous activities within our website.

Hematology in Clinical Practice

About Via Medica Advertising
Bookstore (Ikamed) TVMed
News
Copyright © 2023 Via Medica Regulations Cookie policy Privacy policy Legal Notice