Vol 10, No 4 (2019)
Case report
Published online: 2020-04-23

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Progressive multifocal leukoencephalopathy in patient with diffuse large B-cell lymphoma and acquired immunodeficiency syndrome

Katarzyna Brzeźniakiewicz-Janus12, Agnieszka Lewosiuk12, Zuzanna Walkowiak12, Wojciech Pauli3, Grzegorz Rutkowski4, Miłosz Parczewski5, Mirosław Franków12
Hematologia 2019;10(4):184-196.


Diffused large B-cell lymphoma (DLBCL) is an agressive and one of the most common lymphomas. The treatment of choice is R-CHOP (rituximab, cyclophosphamide, doxorubicine, vincristine, prednisone) immunochemotherapy. In some cases also radiotherapy is indicated. DLBCL and other non-Hodgkin lymphomas maybe an acquired immune deficiency syndrome defining condition in human immunodeficiency virus (HIV) infection, and therefore indication for testing for this virus. Not only HIV infection, but lymphoma as well as immunotherapy may lead to John Cunningham virus reactivation and development of the progressive multifocal leukoencephalopathy.

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Hematology in Clinical Practice