The role of viral infection induced alloreactivity in patients with allogeneic hematopoietic stem cell transplantations
Abstract
Viral infection activated alloreactive peripheral memory T-cells present in the host are considered as one of the causes of transplant related complications during post-transplant period of unrelated donor and haploidentical graft transplantation procedures. Antibody and T-cell receptor coding genes homology and their analogous rearrangement process help to understand cellular and humoral alloreactivity, mediated by alloreactive memory T-cells and antibodies, respectively. Simple tests using single antigen presenting cells or human leukocyte antigen (HLA)-mismatched recipient peripheral blood mononuclear cells vs. virus specific donor T-cells and more sophisticated natural killer cells degranulation marker assays based on flow cytometry enable to rule out or confirm alloreactivity thus increasing the chance of appropriate post-transplant treatment path selection.
Keywords: alloreactivitycross reactivityhypervariable regionsimmunoadoptive therapyimmunodominance hierarchyimmunodominant peptideRSS regionsSAL cellsV(D)J recombinatio
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