Planned pregnancy pregnancy in patient with chronic myelogenous leukemia treated with imatinib
Abstract
Tyrosine kinase inhibitors (TKI) used in the treatment of chronic myelogenous leukemia (CML) can cause disturbances in fetal development in pregnant women. Women of childbearing potential are recommended to practice effective contraception. Women who want to become pregnant should stopped treatment with TKI before and during pregnancy. The optimal time to stop treatment is deep molecular response after minimum 2 years of treatment. We present a case study of a 24-year- -old female patient with CML, diagnosed in myeloblastic phase. After treatment with imatinib deep and permanent molecular remission was achieved. Treatment was interrupted after 5 years in order to become pregnant. During pregnancy increase in BCR-ABL1 transcript was observed and treatment with interferon a was introduced. The baby was healthy. The imatinib was reintroduced, after 3 months deep molecular response was achieved.
Keywords: chronic myelogenous leukemiapregnancy
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