Advances in the diagnosis and treatment of patients with chronic lymphocytic leukemia
Abstract
Significant strides in understanding the biology of chronic lymphocytic leukaemia (CLL) have recently been made, thereby resulting in the development of more effective therapies. Several clinical trials support the key role that immunotherapy and targeted drugs play for managing patient treatment in those either newly diagnosed or with relapsed/refractory CLL. Furthermore, kinase inhibitors participating in B-cell receptor signalling pathways have been currently approved in treating patients suffering this condition. A summary review is hereby presented describing the most relevant achievements made within this field over the last 5 years.
Keywords: chronic lymphocytic leukemiaimmunochemotherapyBCR inhibitorsBCL2 inhibitorsCAR lymphocytesallogeneic hematopoietic stem cells transplantation