open access

Vol 13, No 1 (2022)
Case report
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Midostaurin in the treatment of a patient with acute myeloid leukaemia with FLT3-TKD mutation and NPM1 mutation

Aleksander Salomon-Perzyński1, Urszula Walczak1, Kinga Kos-Zakrzewska1, Ewa Lech-Marańda1, Bożena Katarzyna Budziszewska1
DOI: 10.5603/HCP.2022.0006
·
Hematology in Clinical Practice 2022;13(1):37-40.
Affiliations
  1. Department of Haematology, Institute of Haematology and Transfusion Medicine, Warsaw, Poland

open access

Vol 13, No 1 (2022)
CASE REPORTS

Abstract

Acute myeloid leukaemia (AML) is aggressive cancer with a diverse clinical course which mainly results from the heterogeneous and complex molecular landscape of the disease. For some genetic alterations, in particular mutations in the FMS-like tyrosine kinase 3 (FLT3) gene, the prognosis of patients with newly diagnosed AML depends on the coexistence of other genetic disorders. A thorough understanding of the interactions between mutations is key to improving risk stratification in newly diagnosed AML and personalizing therapy. The addition of midostaurin, an FLT3 tyrosine kinase inhibitor, to standard chemotherapy improved outcomes in the unfavourable prognostic group of AML patients. This research describes a therapeutic strategy in a patient with newly diagnosed AML with FLT3-tyrosine kinase domain (TKD) mutation and wild-type NPM1 who has received a standard remission induction and consolidation chemotherapy in combination with midostaurin, followed by maintenance therapy with an FLT3 inhibitor and haploidentical allogeneic hematopoietic stem cell transplantation.

Abstract

Acute myeloid leukaemia (AML) is aggressive cancer with a diverse clinical course which mainly results from the heterogeneous and complex molecular landscape of the disease. For some genetic alterations, in particular mutations in the FMS-like tyrosine kinase 3 (FLT3) gene, the prognosis of patients with newly diagnosed AML depends on the coexistence of other genetic disorders. A thorough understanding of the interactions between mutations is key to improving risk stratification in newly diagnosed AML and personalizing therapy. The addition of midostaurin, an FLT3 tyrosine kinase inhibitor, to standard chemotherapy improved outcomes in the unfavourable prognostic group of AML patients. This research describes a therapeutic strategy in a patient with newly diagnosed AML with FLT3-tyrosine kinase domain (TKD) mutation and wild-type NPM1 who has received a standard remission induction and consolidation chemotherapy in combination with midostaurin, followed by maintenance therapy with an FLT3 inhibitor and haploidentical allogeneic hematopoietic stem cell transplantation.

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Keywords

acute myeloid leukaemia, FLT3-TKD mutation, midostaurin, haploidentical hematopoietic stem cell transplantation

About this article
Title

Midostaurin in the treatment of a patient with acute myeloid leukaemia with FLT3-TKD mutation and NPM1 mutation

Journal

Hematology in Clinical Practice

Issue

Vol 13, No 1 (2022)

Article type

Case report

Pages

37-40

Page views

1899

Article views/downloads

117

DOI

10.5603/HCP.2022.0006

Bibliographic record

Hematology in Clinical Practice 2022;13(1):37-40.

Keywords

acute myeloid leukaemia
FLT3-TKD mutation
midostaurin
haploidentical hematopoietic stem cell transplantation

Authors

Aleksander Salomon-Perzyński
Urszula Walczak
Kinga Kos-Zakrzewska
Ewa Lech-Marańda
Bożena Katarzyna Budziszewska

References (14)
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