open access

Vol 13, No 1 (2022)
Case report
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Treatment of a patient with acute myeloid leukaemia with FLT3-ITD mutation

Katarzyna Jerzmanowska1, Agnieszka Pluta1
DOI: 10.5603/HCP.2022.0005
·
Hematology in Clinical Practice 2022;13(1):31-36.
Affiliations
  1. Department of Haematology, Medical University of Lodz, Łódź, Poland

open access

Vol 13, No 1 (2022)
CASE REPORTS

Abstract

Acute myeloid leukaemia (AML) is an aggressive myeloid malignancy characterized by ineffective haematopoiesis. A hallmark of AML is unusual cytogenetic and molecular diversity, which determines treatment and has a major impact on patient response to treatment and survival. The mutations most detected in AML are those in the FMS-like tyrosine kinase 3 gene (FLT3). A case report is presented of a patient with AML with FLT3-ITD mutation who was treated with standard induction and consolidation chemotherapy in combination with midostaurin.

Abstract

Acute myeloid leukaemia (AML) is an aggressive myeloid malignancy characterized by ineffective haematopoiesis. A hallmark of AML is unusual cytogenetic and molecular diversity, which determines treatment and has a major impact on patient response to treatment and survival. The mutations most detected in AML are those in the FMS-like tyrosine kinase 3 gene (FLT3). A case report is presented of a patient with AML with FLT3-ITD mutation who was treated with standard induction and consolidation chemotherapy in combination with midostaurin.

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Keywords

AML, FLT3, midostaurin

About this article
Title

Treatment of a patient with acute myeloid leukaemia with FLT3-ITD mutation

Journal

Hematology in Clinical Practice

Issue

Vol 13, No 1 (2022)

Article type

Case report

Pages

31-36

Page views

1838

Article views/downloads

140

DOI

10.5603/HCP.2022.0005

Bibliographic record

Hematology in Clinical Practice 2022;13(1):31-36.

Keywords

AML
FLT3
midostaurin

Authors

Katarzyna Jerzmanowska
Agnieszka Pluta

References (25)
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