Vol 12, No 1 (2021)
Case report
Published online: 2021-04-07

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Effectiveness and safety of ixazomib–lenalidomide–dexamethasone in high-cytogenetic-risk relapsed/refractory multiple myeloma — results of the Polish Myeloma Group observational study

Marek Hus1, Aneta Szudy-Szczyrek1, Michał Mielnik1, Paweł Leszek Bernatowicz2, Jarosław Piszcz3, Agnieszka Druzd-Sitek4, Maria Czyżewska5, Maciej Putowski6, Krzysztof Giannopoulos
DOI: 10.5603/HCP.2021.0002
Hematology in Clinical Practice 2021;12(1):8-17.


The survival of patients with multiple myeloma (MM) has significantly improved in recent years due to the introduction of new drugs such as proteasome inhibitors (PI) or immunomodulatory drugs (ImiDs). However, MM is still an incurable condition, with very variable clinical course.

The group of patients with especially poor prognosis are individuals with relapsed/refractory multiple myeloma (RRMM) with specific cytogenetic disorders — del(17p), t(4;14), t(14;16). Among the therapies that are currently in use the ixazomib–lenalidomid–dexamethasone (IRd) is considered as a candidate to improve outcome.

In this study, we analyzed the cases of patients diagnosed with high-risk molecular RRMM, who have been treated with the IRd chemotherapy regimen. An aggressive case report with no known cytogenetic data was also added. The data was collected from four centers in Poland as part of the Polish Myeloma Group observational study.

The results suggest high efficacy and good safety profile of IRd therapy in patients with RRMM and unfavorable cytogenetics.

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