Osteoporosis in systemic mastocytosis — current therapeutic options based on a clinical case report
, 2, 3, 3, 45, 45
Abstract
Systemic mastocytosis (SM) is a rare hematologic neoplastic disorder characterized by infiltration of various organs by clonal mast cells. It is characterized by cutaneous and organ involvement (hepatosplenomegaly, osteolytic lesions, pathological fractures) and systemic symptoms related to the release of anaphylaxis mediators. Based on the 5th Edition of the World Health Organization (WHO-5) criteria and the International Consensus Classification (ICC) systems, systemic mastocytosis was diagnosed in a 50-year-old patient. The disease course included fractures of the TH11 and L1 vertebrae, and densitometric tests revealed low bone mineral density (BMD). The patient was treated with risedronate for 3 years, however treatment was discontinued due to side effects such as abdominal pain and nausea. The therapy was switched to intravenous zoledronic acid, resulting in a significant increase in BMD in control tests and relief from pain. No new osteoprotic fractures were observed during the treatment.
Keywords: mastocytosisosteoporosistreatmentbisphosphonates
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