Vol 14 (2023): Continuous Publishing
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Published online: 2024-04-17

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Coexistence of chronic lymphocytic leukemia and NK/T lymphoma of the nasopharynx in a patient treated with ibrutinib

Aleksandra Rogowska1, Agnieszka Końska1, Monika Prochorec-Sobieszek23, Bożena Katarzyna Budziszewska1, Ewa Lech-Marańda1, Bartosz Puła1
Hematology in Clinical Practice 2023;14:64-68.


Extranodal NK/T-nasal cell lymphoma is rare in Europe and North America. This report presents a case of a female chronic lymphocytic leukemia patient who developed an extranodal NK/T lymphoma of the nasopharynx shortly after the withdrawal of ibrutinib therapy.

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  1. Eichhorst B, Robak T, Montserrat E, et al. ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org. Chronic lymphocytic leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2021; 32(1): 23–33.
  2. Hallek M, Al-Sawaf O. Chronic lymphocytic leukemia: 2022 update on diagnostic and therapeutic procedures. Am J Hematol. 2021; 96(12): 1679–1705.
  3. Döhner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med. 2000; 343(26): 1910–1916.
  4. Jamroziak K, Puła B, Walewski J. Current treatment of chronic lymphocytic leukemia. Curr Treat Options Oncol. 2017; 18(1): 5.
  5. Puła B, Salomon-Perzyński A, Prochorec-Sobieszek M, et al. Immunochemotherapy for Richter syndrome: current insights. Immunotargets Ther. 2019; 8: 1–14.
  6. Hus I, Giannopoulos K, Jamroziak K, et al. Diagnostic and therapeutic recommendations of the Polish Society of Haematologists and Transfusiologists and Polish Adult Leukemia Group-CLL for chronic lymphocytic leukemia in 2021. Hematol Clin Pract. 2021; 12(2): 37–66.
  7. Pula B, Iskierka-Jazdzewska E, Dlugosz-Danecka M, et al. Long-term efficacy of ibrutinib in relapsed or refractory chronic lymphocytic leukemia: results of the polish adult leukemia study group observational study. Anticancer Res. 2020; 40(7): 4059–4066.
  8. Iskierka-Jażdżewska E, Puła B, Szeremet A, et al. Ibrutinib discontinuation in patients with relapsed or refractory chronic lymphocytic leukemia treated in acompassionate use program: a report from the Polish Adult Leukemia Study Group (PALG). Adv Clin Exp Med. 2019; 28(8): 1051–1057.
  9. Szmit S, Hus I, Giannopoulos K, et al. Recommendations on cardiac safety during ibrutinib therapy. Acta Haematol Pol. 2023; 54(1): 3–5.
  10. Sokołowska B, Jawniak D, Nowaczyńska A, et al. Studies on platelet function during the first year of ibrutinib treatment in patients with chronic lymphocytic leukemia. Acta Haematol Pol. 2022; 53(6): 416–420.
  11. Shen Y, Coyle L, Kerridge I, et al. Second primary malignancies in chronic lymphocytic leukaemia: skin, solid organ, haematological and Richter's syndrome. EJHaem. 2022; 3(1): 129–138.
  12. Sośnia O, Puła B. Chronic lymphocytic leukemia following venetoclax treatment failure. Acta Haematol Pol. 2022; 53(2): 94–103.
  13. Jamroziak K, Szymczyk , Hus M, et al. Hodgkin's variant of Richter's transformation during ibrutinib therapy in a series of CLL patients; the Polish Adult Leukemia Group report (PALG). Eur J Haematol. 2018; 100(4): 389–391.
  14. Chi J, Park J, Saif MW. Ibrutinib-Induced vasculitis in a patient with metastatic colon cancer treated in combination with cetuximab. Case Rep Oncol Med. 2020; 2020: 6154213.
  15. Iberri DJ, Kwong BY, Stevens LA, et al. Ibrutinib-associated rash: a single-centre experience of clinicopathological features and management. Br J Haematol. 2018; 180(1): 164–166.
  16. Hammel JA, Roth GM, Ferguson N, et al. Lower extremity ecchymotic nodules in a patient being treated with ibrutinib for chronic lymphocytic leukemia. JAAD Case Rep. 2017; 3(3): 178–179.
  17. Fabbro SK, Smith SM, Dubovsky JA, et al. Panniculitis in patients undergoing treatment with the bruton tyrosine kinase inhibitor ibrutinib for lymphoid leukemias. JAMA Oncol. 2015; 1(5): 684–686.
  18. Petrackova A, Turcsanyi P, Papajik T, et al. Revisiting Richter transformation in the era of novel CLL agents. Blood Rev. 2021; 49: 100824.
  19. Abi-Rafeh J, Beamish IV, Haegert DG, et al. Extranodal NK/T cell lymphoma and lymphomatoid granulomatosis in a patient with chronic lymphocytic leukaemia: Case report for a new perspective on Richter syndrome. Medicine (Baltimore). 2020; 99(19): e20106.
  20. Ge H, Wu X, Shen J, et al. A case report of extranodal NK/T-cell lymphoma in patient with chronic lymphocytic leukemia. Medicine (Baltimore). 2018; 97(30): e11619.
  21. Allen PB, Lechowicz MJo. Management of NK/T-cell lymphoma, nasal type. J Oncol Pract. 2019; 15(10): 513–520.
  22. Tse E, Zhao WL, Xiong J, et al. How we treat NK/T-cell lymphomas. J Hematol Oncol. 2022; 15(1): 74.

Hematology in Clinical Practice