Vol 13, No 1 (2022)
Case report
Published online: 2022-03-31

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Treatment of a patient with acute myeloid leukaemia with FLT3-ITD mutation

Katarzyna Jerzmanowska1, Agnieszka Pluta1
Hematology in Clinical Practice 2022;13(1):31-36.


Acute myeloid leukaemia (AML) is an aggressive myeloid malignancy characterized by ineffective haematopoiesis. A hallmark of AML is unusual cytogenetic and molecular diversity, which determines treatment and has a major impact on patient response to treatment and survival. The mutations most detected in AML are those in the FMS-like tyrosine kinase 3 gene (FLT3). A case report is presented of a patient with AML with FLT3-ITD mutation who was treated with standard induction and consolidation chemotherapy in combination with midostaurin.

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Hematology in Clinical Practice