Vol 8, No 2 (2017)
Case report
Published online: 2017-09-06

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Coexistence of plasma cell dyscrasias and myelodysplastic syndrome — study of cases and review of literature

Aleksandra Gołos1, Anna Paczek1, Ewa Lech-Marańda12, Krzysztof Warzocha1, Joanna Góra-Tybor1
Hematologia 2017;8(2):144-151.

Abstract

The improvement in plasma cell myeloma (PCM) treatment and much longer overall survival of the patients led to the observation of long-term complications of the therapy. These include secondary malignancies, such as myelodysplastic syndromes (MDS) and acute myeloid leukemia. Definitely less common is the co-occurrence of MDS at the point of diagnosis of PCM or MDS evolving during the observation of untreated patients with monoclonal gammapathy of undetermined significance. In the article we describe 5 patients: one with a therapy-related MDS, the co-occurrence of both diseases from the diagnosis and MDS preceding PCM for several years.

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Hematology in Clinical Practice