Vol 5, No 3 (2014)
Review paper
Published online: 2014-11-20
Advances in the management of von Willebrand disease
Hematologia 2014;5(3):203-212.
Abstract
Recent discoveries shed new insights into the molecular pathogenesis and clinical picture of von Willebrand disease (vWD), a very heterogeneous bleeding disorder. We present the newest publications, important from the clinical and scientific point of view, concerning predominantly the causative mutations within the von Willebrand factor (vWF) gene, the pathogenesis of type 1 of vWD, new methods of assessment of vWF plasma activity and the role of standardized bleeding questionnaires in the diagnostic process of vWD.
Keywords: von Willebrand factorvon Willebrand diseasebleeding disordervon Willebrand factor propeptide