Vol 5, No 3 (2014)
Review paper
Published online: 2014-11-20

open access

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Advances in the management of von Willebrand disease

Joanna Zdziarska, Teresa Iwaniec, Jacek Musiał, Aleksander B. Skotnicki
Hematologia 2014;5(3):203-212.

Abstract

Recent discoveries shed new insights into the molecular pathogenesis and clinical picture of von Willebrand disease (vWD), a very heterogeneous bleeding disorder. We present the newest publications, important from the clinical and scientific point of view, concerning predominantly the causative mutations within the von Willebrand factor (vWF) gene, the pathogenesis of type 1 of vWD, new methods of assessment of vWF plasma activity and the role of standardized bleeding questionnaires in the diagnostic process of vWD.




Hematology in Clinical Practice