open access

Vol 4, No 4 (2013)
Review paper
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Molecular oncogenic defects in subtypes of diffuse large B-cell lymphoma

Marta Bielska, Ewa Lech-Marańda, Agata Pastorczak, Wojciech Młynarski
Hematologia 2013;4(4):333-338.

open access

Vol 4, No 4 (2013)
REVIEW ARTICLES

Abstract

Diffuse large B-cell lymphoma (DLBCL), which is characterized by the uncontrolled growth of mature, peripheral B-cells, constitutes a group of heterogeneous diseases in terms of morphological, biological and clinical features. The classification of DLBCL based on the location of the tumor, his­topathology, immunophenotype, etiology, and similarity to other diseases of the B lymphocytes. This review presents an update on the molecular abnormalities identified in the major subtypes of the disease, e.g. germinal center B-cell and activated B-cell, and their importance in context of the clinical course of disease.

Abstract

Diffuse large B-cell lymphoma (DLBCL), which is characterized by the uncontrolled growth of mature, peripheral B-cells, constitutes a group of heterogeneous diseases in terms of morphological, biological and clinical features. The classification of DLBCL based on the location of the tumor, his­topathology, immunophenotype, etiology, and similarity to other diseases of the B lymphocytes. This review presents an update on the molecular abnormalities identified in the major subtypes of the disease, e.g. germinal center B-cell and activated B-cell, and their importance in context of the clinical course of disease.

Get Citation

Keywords

diffuse large B-cell lymphoma, molecular abnormalities, prognostic factors

About this article
Title

Molecular oncogenic defects in subtypes of diffuse large B-cell lymphoma

Journal

Hematology in Clinical Practice

Issue

Vol 4, No 4 (2013)

Article type

Review paper

Pages

333-338

Bibliographic record

Hematologia 2013;4(4):333-338.

Keywords

diffuse large B-cell lymphoma
molecular abnormalities
prognostic factors

Authors

Marta Bielska
Ewa Lech-Marańda
Agata Pastorczak
Wojciech Młynarski

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