open access

Vol 4, No 4 (2013)
Review paper
Published online: 2014-02-06
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Current management of acute promyelocytic leukemia

Agnieszka Wierzbowska, Aleksandra Gołos
Hematologia 2013;4(4):291-300.

open access

Vol 4, No 4 (2013)
REVIEW ARTICLES
Published online: 2014-02-06

Abstract

Acute promyelocytic leukemia (APL) deserves a special place among neoplasms. It is the first neo­plasma which the targeted therapy at the molecular level was used in. The addiction of all-trans retinoic acid to the standard, anthracycline-based chemotherapy has hugely improved the complete remission rate. The use of arsenic trioxide (ATO) has further improved the clinical outcome of relapsed and refractory APL. Recently, many studies have been conducted to investigate the use of ATO as a front-line therapy. The article shows the latest recommendations for the management of APL.

Abstract

Acute promyelocytic leukemia (APL) deserves a special place among neoplasms. It is the first neo­plasma which the targeted therapy at the molecular level was used in. The addiction of all-trans retinoic acid to the standard, anthracycline-based chemotherapy has hugely improved the complete remission rate. The use of arsenic trioxide (ATO) has further improved the clinical outcome of relapsed and refractory APL. Recently, many studies have been conducted to investigate the use of ATO as a front-line therapy. The article shows the latest recommendations for the management of APL.

Get Citation

Keywords

acute promyelocytic leukemia, PML-RARA, diagnosis, treatment

About this article
Title

Current management of acute promyelocytic leukemia

Journal

Hematology in Clinical Practice

Issue

Vol 4, No 4 (2013)

Article type

Review paper

Pages

291-300

Published online

2014-02-06

Bibliographic record

Hematologia 2013;4(4):291-300.

Keywords

acute promyelocytic leukemia
PML-RARA
diagnosis
treatment

Authors

Agnieszka Wierzbowska
Aleksandra Gołos

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