open access

Vol 4, No 3 (2013)
Review paper
Published online: 2013-11-13
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The infl uence of glucose metabolism on diagnosis and treatment of myeloid and lymphoid malignancies

Agata Malenda, Dominika Anna Nowis
Hematologia 2013;4(3):227-238.

open access

Vol 4, No 3 (2013)
REVIEW ARTICLES
Published online: 2013-11-13

Abstract

A growing number of studies is currently carried out to determine the alterations in cellular metabolism of tumor cells and their infl uence on proliferation of cells and tumor growth. The survival of tumor cells depends on the availability of nutrients, mainly glucose. Glucose in a tumor ismetabolized primarily in the process of glycolysis, which takes place even under unlimited oxygen availability. In this review, we present the current view of interactions between metabolic and signaling pathways in cancer cells, with hematological malignancies as a major focus. We also discuss potential applications of metabolism-modulating agents in the diagnosis and therapy of tumors.

Abstract

A growing number of studies is currently carried out to determine the alterations in cellular metabolism of tumor cells and their infl uence on proliferation of cells and tumor growth. The survival of tumor cells depends on the availability of nutrients, mainly glucose. Glucose in a tumor ismetabolized primarily in the process of glycolysis, which takes place even under unlimited oxygen availability. In this review, we present the current view of interactions between metabolic and signaling pathways in cancer cells, with hematological malignancies as a major focus. We also discuss potential applications of metabolism-modulating agents in the diagnosis and therapy of tumors.
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Keywords

glucose metabolism, oncogenes, diagnosis, therapy

About this article
Title

The infl uence of glucose metabolism on diagnosis and treatment of myeloid and lymphoid malignancies

Journal

Hematology in Clinical Practice

Issue

Vol 4, No 3 (2013)

Article type

Review paper

Pages

227-238

Published online

2013-11-13

Bibliographic record

Hematologia 2013;4(3):227-238.

Keywords

glucose metabolism
oncogenes
diagnosis
therapy

Authors

Agata Malenda
Dominika Anna Nowis

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