open access

Vol 4, No 2 (2013)
Review paper
Published online: 2013-06-25
Get Citation

Hematopathological diagnosis of ”grey zone” lymphomas

Monika Prochorec-Sobieszek, Anna Szumera-Ciećkiewicz
Hematologia 2013;4(2):114-122.

open access

Vol 4, No 2 (2013)
REVIEW ARTICLES
Published online: 2013-06-25

Abstract

The World Health Organization (WHO) classification of hematopoietic neoplasms distinguish
individual histoclinical entities on the basis of integrated morphological, immunohistochemical, genetical
and clinical evaluation. Nevertheless, some of them can’t be precisely categorized although
significant progress in the experimental and clinical studies was made. Selected aggressive B-cell
lymphomas with clinical and biological overlapping between two different types of lymphomas are
incorporated into grey zone lymphomas. The diagnostic challenge has not only theoretical aspects
but crucially affects treatment options. In this article authors present criteria and diagnostic pitfalls
of two grey zone lymphomas in WHO classification: B-cell lymphoma, unclassifiable, with features
intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma and B-cell
lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma Burkitt
lymphoma. Moreover, diagnostic spectrum of lymphomas is discussed.

Abstract

The World Health Organization (WHO) classification of hematopoietic neoplasms distinguish
individual histoclinical entities on the basis of integrated morphological, immunohistochemical, genetical
and clinical evaluation. Nevertheless, some of them can’t be precisely categorized although
significant progress in the experimental and clinical studies was made. Selected aggressive B-cell
lymphomas with clinical and biological overlapping between two different types of lymphomas are
incorporated into grey zone lymphomas. The diagnostic challenge has not only theoretical aspects
but crucially affects treatment options. In this article authors present criteria and diagnostic pitfalls
of two grey zone lymphomas in WHO classification: B-cell lymphoma, unclassifiable, with features
intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma and B-cell
lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma Burkitt
lymphoma. Moreover, diagnostic spectrum of lymphomas is discussed.
Get Citation

Keywords

grey zone lymphomas, B-cell lymphoma unclassifiable

About this article
Title

Hematopathological diagnosis of ”grey zone” lymphomas

Journal

Hematology in Clinical Practice

Issue

Vol 4, No 2 (2013)

Article type

Review paper

Pages

114-122

Published online

2013-06-25

Bibliographic record

Hematologia 2013;4(2):114-122.

Keywords

grey zone lymphomas
B-cell lymphoma unclassifiable

Authors

Monika Prochorec-Sobieszek
Anna Szumera-Ciećkiewicz

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