open access

Vol 4, No 2 (2013)
Review paper
Published online: 2013-06-25
Get Citation

PI3K-AKT axis in normal lymphoid development and B-cell tumors. Part I

Maciej Szydłowski, Ewa Jabłońska, Przemysław Juszczyński
Hematologia 2013;4(2):103-113.

open access

Vol 4, No 2 (2013)
REVIEW ARTICLES
Published online: 2013-06-25

Abstract

Understanding the role of signalling pathways in the pathogenesis of B-cell malignancies requires
elucidation of their function in the normal B cell ontogeny. Studies performed so far underscore
the role of the PI3K-AKT signalling cascade and its downstream effectors, especially FOXO
transcription factors, in control of B cell development and in the pathogenesis of various B-cell
tumors. PI3K-AKT-FOXO axis is known to regulate key processes in B cells, such as proliferation,
cell cycle, apoptosis, oxidative stress or DNA damage repair. Herein, we review molecular mechanisms
of the PI3K-AKT-dependent signal transduction, mechanisms modulating activity of the axis
and their impact on early B cell development, peripherial B cell homeostasis and terminal B-cell
differentiation. In the next part of the review, functional consequences of the PI3K-Akt -Foxo
signalling deregulation in B-cell tumors and potential use of molecules modulating activity of the
axis in the treatment of B-cell malignancies will be discussed.

Abstract

Understanding the role of signalling pathways in the pathogenesis of B-cell malignancies requires
elucidation of their function in the normal B cell ontogeny. Studies performed so far underscore
the role of the PI3K-AKT signalling cascade and its downstream effectors, especially FOXO
transcription factors, in control of B cell development and in the pathogenesis of various B-cell
tumors. PI3K-AKT-FOXO axis is known to regulate key processes in B cells, such as proliferation,
cell cycle, apoptosis, oxidative stress or DNA damage repair. Herein, we review molecular mechanisms
of the PI3K-AKT-dependent signal transduction, mechanisms modulating activity of the axis
and their impact on early B cell development, peripherial B cell homeostasis and terminal B-cell
differentiation. In the next part of the review, functional consequences of the PI3K-Akt -Foxo
signalling deregulation in B-cell tumors and potential use of molecules modulating activity of the
axis in the treatment of B-cell malignancies will be discussed.
Get Citation

Keywords

B cell development, PI3K-AKT, FOXO

About this article
Title

PI3K-AKT axis in normal lymphoid development and B-cell tumors. Part I

Journal

Hematology in Clinical Practice

Issue

Vol 4, No 2 (2013)

Article type

Review paper

Pages

103-113

Published online

2013-06-25

Bibliographic record

Hematologia 2013;4(2):103-113.

Keywords

B cell development
PI3K-AKT
FOXO

Authors

Maciej Szydłowski
Ewa Jabłońska
Przemysław Juszczyński

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.