Vol 4, No 1 (2013)
Review paper
Published online: 2010-04-10
Primary central nervous system lymphoma
Hematologia 2013;4(1):7-14.
Abstract
Primary central nervous system lymphoma (PCNSL) is a rare malignancy with aggressive course and unsatisfactory outcome. This lymphoma represents 4–6% of all extranodal lymphomas. Ninety-five percent PCNSLs are diffuse large B-cell lymphomas. The most common symptoms are: focal deficits, personality changes and increased intracranial pressure. High-dose of methotrexate as monotherapy or in combination with high-dose arabinoside cytosine is the fi rst line treatment in patients with PCNSL. Radiotherapy is the treatment option in patients with residual disease and as a salvage therapy in relapsed patients.
Keywords: primary central nervous system lymphomaneurotoxicitychemotherapyradiotherapy
![](https://journals.viamedica.pl/plugins/generic/popups/images/icons/close.png)