Vol 3, No 4 (2012)
Case report
Published online: 2013-01-15
The isolated extramedullary breast relapse in patient with inv(16)(p13;q22) and CBFB-MYH11 acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation — case report and review of the literature
Hematologia 2012;3(4):359-366.
Abstract
Acute myeloid leukemia (AML) occurs extramedullary very rarely as relapse or an isolated
tumor called granulocytic sarcoma. We present a patient with AML and inversion of
16 chromosome including CBFB-MYH11 fusion gene after allogeneic hematopoietic stem cell
transplantation (allo-HSCT). The extramedullary relapse involving right breast was diagnosed
simultaneously with molecular relapse in the bone marrow. The complete remission was
achieved after combined treatment composed of chemo- and radiotherapy. The images in
computed tomography and positron emission tomography confirmed total regression of tumor.
The authors discuss the risk factors in extramedullary relapse occurrence and review major
results of the latest meta-analysis concerning breast relapses of AML.
tumor called granulocytic sarcoma. We present a patient with AML and inversion of
16 chromosome including CBFB-MYH11 fusion gene after allogeneic hematopoietic stem cell
transplantation (allo-HSCT). The extramedullary relapse involving right breast was diagnosed
simultaneously with molecular relapse in the bone marrow. The complete remission was
achieved after combined treatment composed of chemo- and radiotherapy. The images in
computed tomography and positron emission tomography confirmed total regression of tumor.
The authors discuss the risk factors in extramedullary relapse occurrence and review major
results of the latest meta-analysis concerning breast relapses of AML.
Keywords: myeloid sarcomaisolated extramedullary relapseacute myeloid leukemiabreastallogeneic hematopoietic stem cell transplantation
