Vol 3, No 2 (2012)
Case report
Published online: 2012-06-25
Epstein-Barr virus-negative post-transplant lymphoproliferative disorder in a patient after liver transplantation
Hematologia 2012;3(2):181-185.
Abstract
We present a case of 60-years-old woman with post-transplant lymphoproliferative disorder,
EBV-negative, that was diagnosed in the large intestine 5 years after liver transplantation
due to hepatitis B virus infection. The diagnostic procedures and treatment were guided by
the recommendations of the Polish Lymphoma Research Group. Firstly, reduction of
immunosupression was initiated followed by rituximab at a dose of 375 mg/m2 intravenous
every 7 days for 4 weeks. No response was observed and CHOP chemotherapy was added for
subsequent 4 cycles. The patient achieved complete remission (CR) confirmed by a computed
tomography. Unfortunately the patient died being in CR probably due to pulmonary embolism.
EBV-negative, that was diagnosed in the large intestine 5 years after liver transplantation
due to hepatitis B virus infection. The diagnostic procedures and treatment were guided by
the recommendations of the Polish Lymphoma Research Group. Firstly, reduction of
immunosupression was initiated followed by rituximab at a dose of 375 mg/m2 intravenous
every 7 days for 4 weeks. No response was observed and CHOP chemotherapy was added for
subsequent 4 cycles. The patient achieved complete remission (CR) confirmed by a computed
tomography. Unfortunately the patient died being in CR probably due to pulmonary embolism.
Keywords: post-transplant lymphoproliferative disorderEpstein-Barr virusrituximabchemotherapyliver transplantation
