open access

Vol 1, No 2 (2010)
Review paper
Published online: 2010-05-14
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Complications of anticoagulant therapy

Jerzy Windyga
Hematologia 2010;1(2):142-150.

open access

Vol 1, No 2 (2010)
REVIEW ARTICLES
Published online: 2010-05-14

Abstract

Nowadays, anticoagulant therapy is one of the most common form of medical intervention. Among others, it is the mainstay of prophylaxis and treatment of venous thromboembolism. The most important representatives of anticoagulants are heparins (unfractionated heparin and low-molecular-weight heparin) and coumarin derivatives (vitamin K antagonists). Newer anticoagulants are represented by selective - indirect or antithrombin-dependent (fondaparinux) and direct or antithrombin-independent (rivaroxaban) - inhibitors of clotting factor Xa, and selective direct thrombin inhibitors (dabigatran). Besides numerous advantages anticoagulants have also drawbacks. The aim of this paper is to discuss the principles of management of anticoagulant-associated complications.

Abstract

Nowadays, anticoagulant therapy is one of the most common form of medical intervention. Among others, it is the mainstay of prophylaxis and treatment of venous thromboembolism. The most important representatives of anticoagulants are heparins (unfractionated heparin and low-molecular-weight heparin) and coumarin derivatives (vitamin K antagonists). Newer anticoagulants are represented by selective - indirect or antithrombin-dependent (fondaparinux) and direct or antithrombin-independent (rivaroxaban) - inhibitors of clotting factor Xa, and selective direct thrombin inhibitors (dabigatran). Besides numerous advantages anticoagulants have also drawbacks. The aim of this paper is to discuss the principles of management of anticoagulant-associated complications.
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Keywords

heparin; oral anticoagulants; pentasaccharides; Xa-inhibitors; thrombin inhibitors; bleeding; HITT; skin necrosis

About this article
Title

Complications of anticoagulant therapy

Journal

Hematology in Clinical Practice

Issue

Vol 1, No 2 (2010)

Article type

Review paper

Pages

142-150

Published online

2010-05-14

Page views

940

Article views/downloads

22675

Bibliographic record

Hematologia 2010;1(2):142-150.

Keywords

heparin
oral anticoagulants
pentasaccharides
Xa-inhibitors
thrombin inhibitors
bleeding
HITT
skin necrosis

Authors

Jerzy Windyga

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