open access

Vol 2, No 1 (2011)
Review paper
Published online: 2011-03-24
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Prognostic and therapeutic implications of genetic aberrations in childhood acute lymphoblastic leukemia

Agata Pastorczak, Wojciech Młynarski, Tomasz Szczepański
Hematologia 2011;2(1):43-50.

open access

Vol 2, No 1 (2011)
REVIEW ARTICLES
Published online: 2011-03-24

Abstract

The process of malignant transformation in childhood acute lymphoblastic leukemia (ALL) requires at least two subsequent mutations which initiate and promote leukemogenesis. These genetic aberrations include point-mutations as well as double-strand DNA breaks leading to various types of chromosomal rearrangements of the coding regions. Some of the genetic lesions are independent prognostic factors, which effectively stratify the risk of treatment outcome. In this review we summarize the most common genetic aberrations in childhood ALL which may provide potential molecular target for novel therapies.
Hematologia 2011; 2, 1: 43–50

Abstract

The process of malignant transformation in childhood acute lymphoblastic leukemia (ALL) requires at least two subsequent mutations which initiate and promote leukemogenesis. These genetic aberrations include point-mutations as well as double-strand DNA breaks leading to various types of chromosomal rearrangements of the coding regions. Some of the genetic lesions are independent prognostic factors, which effectively stratify the risk of treatment outcome. In this review we summarize the most common genetic aberrations in childhood ALL which may provide potential molecular target for novel therapies.
Hematologia 2011; 2, 1: 43–50
Get Citation

Keywords

acute lymphoblastic leukemia; genetic aberrations; treatment

About this article
Title

Prognostic and therapeutic implications of genetic aberrations in childhood acute lymphoblastic leukemia

Journal

Hematology in Clinical Practice

Issue

Vol 2, No 1 (2011)

Article type

Review paper

Pages

43-50

Published online

2011-03-24

Bibliographic record

Hematologia 2011;2(1):43-50.

Keywords

acute lymphoblastic leukemia
genetic aberrations
treatment

Authors

Agata Pastorczak
Wojciech Młynarski
Tomasz Szczepański

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