Vol 2, No 1 (2011)
Review paper
Published online: 2011-03-24

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Prognostic and therapeutic implications of genetic aberrations in childhood acute lymphoblastic leukemia

Agata Pastorczak, Wojciech Młynarski, Tomasz Szczepański
Hematologia 2011;2(1):43-50.

Abstract

The process of malignant transformation in childhood acute lymphoblastic leukemia (ALL) requires at least two subsequent mutations which initiate and promote leukemogenesis. These genetic aberrations include point-mutations as well as double-strand DNA breaks leading to various types of chromosomal rearrangements of the coding regions. Some of the genetic lesions are independent prognostic factors, which effectively stratify the risk of treatment outcome. In this review we summarize the most common genetic aberrations in childhood ALL which may provide potential molecular target for novel therapies.
Hematologia 2011; 2, 1: 43–50

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Hematology in Clinical Practice