open access

Vol 2, No 2 (2011)
Review paper
Published online: 2011-07-15
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Hematological complications in patients with viral hepatitis

Magdalena Wrotkowska, Piotr Stalke, Tomasz Smiatacz, Jan Maciej Zaucha
Hematologia 2011;2(2):162-171.

open access

Vol 2, No 2 (2011)
REVIEW ARTICLES
Published online: 2011-07-15

Abstract

Over 2000 new hepatitis C virus (HCV) infections, 1500 new hepatitis B virus (HBV) infections and 100 new hepatitis A virus (HAV) infections are registered in Poland annually. Hepatotropic viruses induce not only liver damage but also extrahepatic manifestations affecting other organs mainly due to autoimmune reactions. Extrahepatic manifestations occur in about 40% of patients suffering from chronic HCV and in 10–20% patients with chronic HBV. The majority of hematological complications in patients with viral hepatitis results from chronic antigen stimulation of B lymphocytes that impairs the immune system and leads to its genetic aberrations. Hematological complications may be the first symptoms of viral hepatitis that otherwise may remain clinically silent. Therefore, the haematologist may be the first one who diagnose viral hepatitis. Hematological complications of all viral hepatitis (A, B, C) comprise of cryoglobulinemia, thrombocytopenia, rarely aplastic anaemia and haemolytic anaemia. B-cell non-Hodgkin lymphomas occur in the course of HBV and HCV, and monoclonal gammapathies mainly of HCV. Close cooperation between hematologist and hepatologist is necessary to provide optimal management of patients with hepatitis and hematological complications.
Hematologia 2011; 2, 2: 162–171

Abstract

Over 2000 new hepatitis C virus (HCV) infections, 1500 new hepatitis B virus (HBV) infections and 100 new hepatitis A virus (HAV) infections are registered in Poland annually. Hepatotropic viruses induce not only liver damage but also extrahepatic manifestations affecting other organs mainly due to autoimmune reactions. Extrahepatic manifestations occur in about 40% of patients suffering from chronic HCV and in 10–20% patients with chronic HBV. The majority of hematological complications in patients with viral hepatitis results from chronic antigen stimulation of B lymphocytes that impairs the immune system and leads to its genetic aberrations. Hematological complications may be the first symptoms of viral hepatitis that otherwise may remain clinically silent. Therefore, the haematologist may be the first one who diagnose viral hepatitis. Hematological complications of all viral hepatitis (A, B, C) comprise of cryoglobulinemia, thrombocytopenia, rarely aplastic anaemia and haemolytic anaemia. B-cell non-Hodgkin lymphomas occur in the course of HBV and HCV, and monoclonal gammapathies mainly of HCV. Close cooperation between hematologist and hepatologist is necessary to provide optimal management of patients with hepatitis and hematological complications.
Hematologia 2011; 2, 2: 162–171
Get Citation

Keywords

viral hepatitis; cryoglobulinemia; thrombocytopenia; non-Hodgkin lymphoma; aplastic anaemia; haemolytic anaemia; monoclonal gammapathies

About this article
Title

Hematological complications in patients with viral hepatitis

Journal

Hematology in Clinical Practice

Issue

Vol 2, No 2 (2011)

Article type

Review paper

Pages

162-171

Published online

2011-07-15

Bibliographic record

Hematologia 2011;2(2):162-171.

Keywords

viral hepatitis
cryoglobulinemia
thrombocytopenia
non-Hodgkin lymphoma
aplastic anaemia
haemolytic anaemia
monoclonal gammapathies

Authors

Magdalena Wrotkowska
Piotr Stalke
Tomasz Smiatacz
Jan Maciej Zaucha

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