open access

Vol 2, No 2 (2011)
Review paper
Published online: 2011-07-15
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Prophylaxis and treatment of gastrointestinal tract dysfunction as side effect of chemotherapy and radiotherapy

Barbara Nasiłowska-Adamska
Hematologia 2011;2(2):149-161.

open access

Vol 2, No 2 (2011)
REVIEW ARTICLES
Published online: 2011-07-15

Abstract

Dysfunction of the digestive tract is a common and serious problem affecting patients with neoplasms treated with chemotherapy, radiotherapy or a combination of both. Mucosal barrier injury, including oral and gastrointestinal mucositis, or nausea and vomiting are the most common and distressing effects of anti-cancer therapy, profoundly influencing quality of life. Patients with mucositis may suffer from painful ulcers of mucosa, bleeding, dysphagia, diarrhea, infections, food intake impairment and require longer periods of hospitalization. Then, mucositis are associated with the significant health and financial costs. In the last decade, a better insight into the pathogenesis of these complications has led to the development of novel therapeutic options and allowed to update guidelines for more effective care of patients with oral and gastrointestinal mucositis and for the prevention of chemotherapy and radiotherapy induced nausea and vomiting.
Hematologia 2011; 2, 2: 149–161

Abstract

Dysfunction of the digestive tract is a common and serious problem affecting patients with neoplasms treated with chemotherapy, radiotherapy or a combination of both. Mucosal barrier injury, including oral and gastrointestinal mucositis, or nausea and vomiting are the most common and distressing effects of anti-cancer therapy, profoundly influencing quality of life. Patients with mucositis may suffer from painful ulcers of mucosa, bleeding, dysphagia, diarrhea, infections, food intake impairment and require longer periods of hospitalization. Then, mucositis are associated with the significant health and financial costs. In the last decade, a better insight into the pathogenesis of these complications has led to the development of novel therapeutic options and allowed to update guidelines for more effective care of patients with oral and gastrointestinal mucositis and for the prevention of chemotherapy and radiotherapy induced nausea and vomiting.
Hematologia 2011; 2, 2: 149–161
Get Citation

Keywords

alimentary mucositis; vomiting; chemotherapy; radiotherapy; prophylaxis; therapy

About this article
Title

Prophylaxis and treatment of gastrointestinal tract dysfunction as side effect of chemotherapy and radiotherapy

Journal

Hematology in Clinical Practice

Issue

Vol 2, No 2 (2011)

Article type

Review paper

Pages

149-161

Published online

2011-07-15

Bibliographic record

Hematologia 2011;2(2):149-161.

Keywords

alimentary mucositis
vomiting
chemotherapy
radiotherapy
prophylaxis
therapy

Authors

Barbara Nasiłowska-Adamska

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