Vol 2, No 4 (2011)
Case report
Published online: 2011-12-28
Cerebral venous and sinus thrombosis complicated by heparin-induced thrombocytopenia
Hematologia 2011;2(4):363-369.
Abstract
Cerebral venous and sinus thrombosis (CVT) is a rare form of venous thromboembolism, with
annual incidence of 2–4 per million. Modern imaging techniques, particularly magnetic resonance
imaging (MRI) combined with MR-venography and computed tomography venography
(CT-v), have greatly improved the diagnosis of CVT. Recently published consensus-based
guidelines on the treatment of CVT recommend therapeutic doses of unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH) for the initial treatment of the disease
followed by vitamin K antagonists for secondary CVT prevention. In this paper, we describe
the management of patient with acute CVT who developed heparin induced thrombocytopenia
thrombosis (HITT) while receiving therapeutic doses of LMWH. This report highlights the
importance of careful monitoring of initial treatment with heparin, and discusses the strategy
of HITT management in Poland, where most anticoagulants licensed for HITT treatment are
virtually not achievable.
Hematologia 2011; 2, 4: 363–369
Hematologia 2011; 2, 4: 363–369
Keywords: cerebral sinus and venous thrombosisheparinheparin-induced thrombocytopeniafondaparinux