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Recurrent cervical adenofibroma progressing to adenosarcoma: a rare case report
Affiliations- Department of Obstetrics and Gynecology,Women and Children’s Hospital of Chongqing Medical University, (Chongqing Health Center for Women and Children),Chongqing, People's Republic of China
- Department of Pathology,Women and Children’s Hospital of Chongqing Medical University (Chongqing Health Center for Women and Children),Chongqing, People's Republic of China
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Abstract
Objectives: Cervical adenofibroma is a rare form of mixed mesodermal tumor that can present as cervical polyps with
a tendency for local recurrence and progression. Few cases progressing to adenosarcoma have previously been reported.
We report a case of cervical adenofibroma progressing to adenosarcoma, and we seek to remind clinicians of the method
and importance of the differential diagnosis of this disease.
Material and methods: A fertile woman was admitted in our department for the eighth recurrence of a cervical polypoidal
mass which for the past 10 years. Recurrence of cervical adenofibroma was confirmed by ultrasound and MRI. A wide
local excision under hysteroscopy was performed due to her strong desire to preserve the uterus.
Results: Surgical pathology and immunohistochemical interpretation revealed cervical adenosarcoma. A hysterectomy
with conservation of the ovaries was recommended, with regular follow-ups for evidence of disease recurrence.
Conclusions: Differential diagnoses of cervical adenofibroma are hard to prove. Adenosarcoma should be ruled out,
especially in women presenting with recurrent cervical polypoidal masses. A combined histological/immunohistochemical
investigation is mandatory.
Abstract
Objectives: Cervical adenofibroma is a rare form of mixed mesodermal tumor that can present as cervical polyps with
a tendency for local recurrence and progression. Few cases progressing to adenosarcoma have previously been reported.
We report a case of cervical adenofibroma progressing to adenosarcoma, and we seek to remind clinicians of the method
and importance of the differential diagnosis of this disease.
Material and methods: A fertile woman was admitted in our department for the eighth recurrence of a cervical polypoidal
mass which for the past 10 years. Recurrence of cervical adenofibroma was confirmed by ultrasound and MRI. A wide
local excision under hysteroscopy was performed due to her strong desire to preserve the uterus.
Results: Surgical pathology and immunohistochemical interpretation revealed cervical adenosarcoma. A hysterectomy
with conservation of the ovaries was recommended, with regular follow-ups for evidence of disease recurrence.
Conclusions: Differential diagnoses of cervical adenofibroma are hard to prove. Adenosarcoma should be ruled out,
especially in women presenting with recurrent cervical polypoidal masses. A combined histological/immunohistochemical
investigation is mandatory.
Keywords
cervical adenofibroma; adenosarcoma; recurrence; histological/immunohistochemical investigation
About this articleTitle
Recurrent cervical adenofibroma progressing to adenosarcoma: a rare case report
Journal
Issue
Article type
Research paper
Pages
4-7
Published online
2023-07-11
Page views
533
Article views/downloads
324
DOI
Pubmed
Bibliographic record
Ginekol Pol 2024;95(1):4-7.
Keywords
cervical adenofibroma
adenosarcoma
recurrence
histological/immunohistochemical investigation
Authors
Li Chen
Yugang Chi
Yanlin Chen
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