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open access

Vol 94, No 11 (2023)
Research paper
Published online: 2023-06-09
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The evaluation of serum brain-derived neurotrophic factor levels in pregnant women with hyperemesis gravidarum

Busra Demir Cendek1, Betul Tokgoz Cakir1, Rahime Bedir Fındık2, Mujde Can Ibanoglu1, Melahat Yildirim2, Huseyin Tugrul Celik1, Ayse Filiz Yavuz3
DOI: 10.5603/GP.a2023.0049
·
Pubmed: 37306163
·
Ginekol Pol 2023;94(11):913-917.
Affiliations
  1. Department of Biochemistry, Yuzuncu Yil Private Hospital, Ankara, Türkiye
  2. Department of Gynecology, T.C. Ministry of Health Ankara City Hospital, Ankara, Türkiye
  3. Department of Gynecology, T.C. Ministry of Health, Ankara City Hospital, Türkiye

open access

Vol 94, No 11 (2023)
ORIGINAL PAPERS Obstetrics
Published online: 2023-06-09

Abstract

Objectives: The aim of this study was to investigate the relationship between levels of brain-derived neurotrophic factor (BDNF), which is considered a cause of conditions such as depression and eating disorders, and hyperemesis gravidarum (HG).

Material and methods: This study was conducted as a prospective study at Ankara Ataturk Training and Research Hospital in the Department of Obstetrics and Gynecology. The study included 73 pregnant women with singleton pregnancies (32 pregnant women with HG and 41 pregnant women without hyperemesis). Serum BDNF levels were compared between the two groups.

Results: The mean age of the study group was 27.3 ± 3.5 years and the body mass index (BMI) was 22.4 ± 2.7 kg/m2. There is no statistically significant difference between the study group and the control group in terms of demographic data (p > 0.05). The pregnant women with HG were found to have significantly higher serum BDNF levels compared to the control group (349.1 ± 94.6 pg/mL vs 292. 3 ± 86.01, p = 0.009)

Conclusions: Serum BDNF levels that are low in psychiatric disorders such as depression or anxiety were found as high in pregnant women with HG.

Abstract

Objectives: The aim of this study was to investigate the relationship between levels of brain-derived neurotrophic factor (BDNF), which is considered a cause of conditions such as depression and eating disorders, and hyperemesis gravidarum (HG).

Material and methods: This study was conducted as a prospective study at Ankara Ataturk Training and Research Hospital in the Department of Obstetrics and Gynecology. The study included 73 pregnant women with singleton pregnancies (32 pregnant women with HG and 41 pregnant women without hyperemesis). Serum BDNF levels were compared between the two groups.

Results: The mean age of the study group was 27.3 ± 3.5 years and the body mass index (BMI) was 22.4 ± 2.7 kg/m2. There is no statistically significant difference between the study group and the control group in terms of demographic data (p > 0.05). The pregnant women with HG were found to have significantly higher serum BDNF levels compared to the control group (349.1 ± 94.6 pg/mL vs 292. 3 ± 86.01, p = 0.009)

Conclusions: Serum BDNF levels that are low in psychiatric disorders such as depression or anxiety were found as high in pregnant women with HG.

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Keywords

hyperemesis gravidarum; psychological factors; brain-derived neurotrophic factor; pregnancy

About this article
Title

The evaluation of serum brain-derived neurotrophic factor levels in pregnant women with hyperemesis gravidarum

Journal

Ginekologia Polska

Issue

Vol 94, No 11 (2023)

Article type

Research paper

Pages

913-917

Published online

2023-06-09

Page views

328

Article views/downloads

258

DOI

10.5603/GP.a2023.0049

Pubmed

37306163

Bibliographic record

Ginekol Pol 2023;94(11):913-917.

Keywords

hyperemesis gravidarum
psychological factors
brain-derived neurotrophic factor
pregnancy

Authors

Busra Demir Cendek
Betul Tokgoz Cakir
Rahime Bedir Fındık
Mujde Can Ibanoglu
Melahat Yildirim
Huseyin Tugrul Celik
Ayse Filiz Yavuz

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