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The use of CO2 laser in vulvar lichen sclerosus treatment — molecular evidence
, 1, 1, 1
Affiliations- Medical University of Silesia, Katowice, Poland
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Abstract
Objectives: Vulvar lichen sclerosus is chronic and difficult to treat disorder, which often is recurrent and leads to multiple complications. The limited efficacy of pharmacologic treatment directed the search for new therapies including use of CO2 laser. The aim of the study was to provide rationale for the use of CO2 laser in treatment of vulvar lichen sclerosus.
Material and methods: Two patients with diagnosed LS were recruited for the study. Vulvar biopsies were taken taken before CO2 laser application and then 3 months later. We assessed the following genes: COL1A, COL1A2, COL3A1, COL5A1, COL5A2, COL5A3, ELN, ECM1, HSPA1A, HSPA1B, SERPINH1, TLL1, TP53, BMP1. We also assessed patients' quality of life by VuAS scale before and after treatment.
Results: In both patients we observed decreased clinical symptoms observed by an experienced gynecologist as well as significant changes in gene expression before and after laser treatment.
Conclusions: Treatment with CO2 laser can be alternatively considered in patients with vulvar lichen sclerosus.
Abstract
Objectives: Vulvar lichen sclerosus is chronic and difficult to treat disorder, which often is recurrent and leads to multiple complications. The limited efficacy of pharmacologic treatment directed the search for new therapies including use of CO2 laser. The aim of the study was to provide rationale for the use of CO2 laser in treatment of vulvar lichen sclerosus.
Material and methods: Two patients with diagnosed LS were recruited for the study. Vulvar biopsies were taken taken before CO2 laser application and then 3 months later. We assessed the following genes: COL1A, COL1A2, COL3A1, COL5A1, COL5A2, COL5A3, ELN, ECM1, HSPA1A, HSPA1B, SERPINH1, TLL1, TP53, BMP1. We also assessed patients' quality of life by VuAS scale before and after treatment.
Results: In both patients we observed decreased clinical symptoms observed by an experienced gynecologist as well as significant changes in gene expression before and after laser treatment.
Conclusions: Treatment with CO2 laser can be alternatively considered in patients with vulvar lichen sclerosus.
Keywords
vulvar lichen sclerosus; CO2 laser; heat shock proteins; collagen; COL1A1; HSPA1A; HSPA1B
About this articleTitle
The use of CO2 laser in vulvar lichen sclerosus treatment — molecular evidence
Journal
Issue
Article type
Research paper
Pages
903-906
Published online
2023-04-20
Page views
501
Article views/downloads
446
DOI
Pubmed
Bibliographic record
Ginekol Pol 2023;94(11):903-906.
Keywords
vulvar lichen sclerosus
CO2 laser
heat shock proteins
collagen
COL1A1
HSPA1A
HSPA1B
Authors
Adrianna Marzec
Anita Olejek
Kamila Stopinska
Wojciech Cnota
Iwona Gabriel
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