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Leptin/SFRP5 ratio as a potential predictor of postpartum weight retention. A prospective pilot study
, 1, 1, 1
Affiliations- Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, Poland
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Abstract
Objectives: Excessive gestational weight gain (EGWG) and failure to lose weight within 6 months from delivery are important and identifiable predictors of the long-term obesity. The aim of the study was to verify clinical usefulness of several substances that had been proved to play a significant role in metabolism and body mass regulation, i.e., leptin, ghrelin, fatty acid binding protein 4 (FABP4), secreted frizzled-related protein 5 (SFRP5), and vaspin, in relation to certain laboratory results, body composition and hydration status of females in the early postpartum period. The main goal was to determine a potential marker, which assessed as early as 48 hours after delivery, could predict serious difficulties in achieving pre pregnancy body mass of women with EGWG six months afterwards. Material and methods: The same inclusion criteria applied to the study group (women with EGWG) as well as the control group (women with appropriate body mass gain in pregnancy). These included normal pre-pregnancy BMI, absence of any diseases prior, during pregnancy and after delivery, 6-month long breastfeeding. Results: Postpartum weight retention (PPWR) depended positively on gestational weight gain as well as the leptin/ /SFRP5 ratio assessed 48 hours after delivery. Conclusions: Both obstetricians and midwives should pay special attention to proper nutrition of pregnant women. The assessment of biophysical and biochemical parameters in the early postpartum period, when the mothers are usually hospitalized, seems to allow to predict the risk of greater body weight retention. Future research will help to determine to what extent the circulating concentrations of leptin and SFRP5 in the early puerperium are important for prediction of maternal PPWR and obesity.
Abstract
Objectives: Excessive gestational weight gain (EGWG) and failure to lose weight within 6 months from delivery are important and identifiable predictors of the long-term obesity. The aim of the study was to verify clinical usefulness of several substances that had been proved to play a significant role in metabolism and body mass regulation, i.e., leptin, ghrelin, fatty acid binding protein 4 (FABP4), secreted frizzled-related protein 5 (SFRP5), and vaspin, in relation to certain laboratory results, body composition and hydration status of females in the early postpartum period. The main goal was to determine a potential marker, which assessed as early as 48 hours after delivery, could predict serious difficulties in achieving pre pregnancy body mass of women with EGWG six months afterwards. Material and methods: The same inclusion criteria applied to the study group (women with EGWG) as well as the control group (women with appropriate body mass gain in pregnancy). These included normal pre-pregnancy BMI, absence of any diseases prior, during pregnancy and after delivery, 6-month long breastfeeding. Results: Postpartum weight retention (PPWR) depended positively on gestational weight gain as well as the leptin/ /SFRP5 ratio assessed 48 hours after delivery. Conclusions: Both obstetricians and midwives should pay special attention to proper nutrition of pregnant women. The assessment of biophysical and biochemical parameters in the early postpartum period, when the mothers are usually hospitalized, seems to allow to predict the risk of greater body weight retention. Future research will help to determine to what extent the circulating concentrations of leptin and SFRP5 in the early puerperium are important for prediction of maternal PPWR and obesity.
Keywords
adipokines; leptin; secreted frizzled-related protein 5; excessive gestational weight gain; bioelectrical impedance analysis; postpartum weight retention
About this articleTitle
Leptin/SFRP5 ratio as a potential predictor of postpartum weight retention. A prospective pilot study
Journal
Issue
Article type
Research paper
Pages
654-662
Published online
2023-04-04
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653
Article views/downloads
335
DOI
Pubmed
Bibliographic record
Ginekol Pol 2023;94(8):654-662.
Keywords
adipokines
leptin
secreted frizzled-related protein 5
excessive gestational weight gain
bioelectrical impedance analysis
postpartum weight retention
Authors
Monika Ruszala
Jolanta Patro-Malysza
Zaneta Kimber-Trojnar
Bozena Leszczynska-Gorzelak
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