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The correlation of vitamin D level with body mass index in women with polycystic ovary syndrome
Affiliations- Department of Gynecology and Obstetrics, Clinic of Gynecological Endocrinology, Medical University of Silesia, Katowice, Poland
- Department of Gynecological and Obstetrics, Women’s and Child Health Center, Medical University of Silesia, Katowice, Poland
- Department of Epidemiology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Poland
- Department of Gynecological Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
- Students Scientific Association of Gynecological Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
open access
Abstract
Objectives: The aim of this study is to analyze correlation between vitamin D level and body mass index (BMI) in polycystic ovary syndrome (PCOS) women.
Material and methods: The study group consisted of 311 patients with PCOS. Patients were categorized according to four phenotypes. All of the women participating in the study had their blood tested in the appropriate phase of the menstrual cycle and after proper preparation for the tests. The ultrasound examination and anthropometric measurements were performed.
Results: Vitamin D concentration was assessed in all study subgroups. The majority of patients had vitamin D deficiency or insufficient level. Variables included in the study, such as level of vitamin D, low density lipoprotein (LDL), sex hormone binding globulin (SHBG), testosterone, androstenedione, Anti-Müllerian Hormone (AMH) and BMI were correlated. A negative correlation was observed with the the level of SHBG, vitamin D and AMH. Subsequently, positive correlations were shown with testosterone, LDL and free testosterone level. An analysis of the correlation between BMI and vitamin D concentration showed that in phenotype I of PCOS this correlation was statistically significant and in the remaining PCOS phenotypes the correlation was close to statistical significance.
Conclusions: Most PCOS patients have a deficiency or insufficient level of vitamin D. Women with PCOS have shown a significant negative correlation between BMI and SHBG serum level and between BMI and AMH level. A positive correlation exists between BMI and total and free testosterone and LDL. There is a negative correlation between BMI and vitamin D level in PCOS patients and in phenotype I this correlation was statistically significant.
Abstract
Objectives: The aim of this study is to analyze correlation between vitamin D level and body mass index (BMI) in polycystic ovary syndrome (PCOS) women.
Material and methods: The study group consisted of 311 patients with PCOS. Patients were categorized according to four phenotypes. All of the women participating in the study had their blood tested in the appropriate phase of the menstrual cycle and after proper preparation for the tests. The ultrasound examination and anthropometric measurements were performed.
Results: Vitamin D concentration was assessed in all study subgroups. The majority of patients had vitamin D deficiency or insufficient level. Variables included in the study, such as level of vitamin D, low density lipoprotein (LDL), sex hormone binding globulin (SHBG), testosterone, androstenedione, Anti-Müllerian Hormone (AMH) and BMI were correlated. A negative correlation was observed with the the level of SHBG, vitamin D and AMH. Subsequently, positive correlations were shown with testosterone, LDL and free testosterone level. An analysis of the correlation between BMI and vitamin D concentration showed that in phenotype I of PCOS this correlation was statistically significant and in the remaining PCOS phenotypes the correlation was close to statistical significance.
Conclusions: Most PCOS patients have a deficiency or insufficient level of vitamin D. Women with PCOS have shown a significant negative correlation between BMI and SHBG serum level and between BMI and AMH level. A positive correlation exists between BMI and total and free testosterone and LDL. There is a negative correlation between BMI and vitamin D level in PCOS patients and in phenotype I this correlation was statistically significant.
Keywords
polycystic ovary syndrome; body mass index; vitamin D
About this articleTitle
The correlation of vitamin D level with body mass index in women with polycystic ovary syndrome
Journal
Issue
Article type
Research paper
Pages
883-888
Published online
2023-04-25
Page views
550
Article views/downloads
515
DOI
Pubmed
Bibliographic record
Ginekol Pol 2023;94(11):883-888.
Keywords
polycystic ovary syndrome
body mass index
vitamin D
Authors
Artur Nowak
Mariusz Wojtowicz
Kamil Baranski
Dominika Galczynska
Jakub Daniluk
Dagmara Pluta
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